Gene coding for the late 11,000-dalton polypeptide of the Tian Tan strain of vaccinia virus and its 5'-flanking region: nucleotide sequence.

A late gene coding for a major structural polypeptide of 11,000 daltons from the Tian Tan strain of vaccinia virus was cloned. A comparison of the sequences from Tian Tan and WR strains of vaccinia virus revealed that there were differences in four nucleotides and one amino acid and that there was little homology between the 5'-flanking sequences of the late and the early genes. However, substantial homology was detected between the 5'-flanking sequences of the late genes.