Literature DB >> 3943625

Fine tuning of ribosomal accuracy.

J Ninio.   

Abstract

If the rate constant for peptide bond formation were high just after an amino acid incorporation and occasionally switched to a lower value afterwards, then the ribosome could compensate for tRNA imbalance specifically at hungry codons. A rigorous analysis of the scheme proves its effectiveness. For instance, a 10-fold reduction in cognate tRNA concentration may increase the error rate by only a factor of two.

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Year:  1986        PMID： 3943625     DOI： 10.1016/0014-5793(86)80202-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Specificity of cell-cell adhesion by classical cadherins: Critical role for low-affinity dimerization through beta-strand swapping.

Authors:  Chien Peter Chen; Shoshana Posy; Avinoam Ben-Shaul; Lawrence Shapiro; Barry H Honig
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-03       Impact factor: 11.205

Review 2.  Errors and alternatives in reading the universal genetic code.

Authors:  J Parker
Journal:  Microbiol Rev       Date:  1989-09

3.  Alternative to the steady-state method: derivation of reaction rates from first-passage times and pathway probabilities.

Authors:  J Ninio
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

4.  Abortive intermediates in transcription by wheat-germ RNA polymerase II. Dynamic aspects of enzyme/template interactions in selection of the enzyme synthetic mode.

Authors:  L de Mercoyrol; J M Soulié; C Job; D Job; C Dussert; J Palmari; M Rasigni; G Rasigni
Journal:  Biochem J       Date:  1990-08-01       Impact factor: 3.857

5.  Codon influence on protein expression in E. coli correlates with mRNA levels.

Authors:  Reka Letso; Helen Neely; W Nicholson Price; Grégory Boël; Kam-Ho Wong; Min Su; Jon Luff; Mayank Valecha; John K Everett; Thomas B Acton; Rong Xiao; Gaetano T Montelione; Daniel P Aalberts; John F Hunt
Journal:  Nature       Date:  2016-01-13       Impact factor: 49.962
  5 in total

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