| Literature DB >> 3943139 |
P E Schwarze, E O Pettersen, P O Seglen.
Abstract
Hepatocytes in the adult rat are normally mostly tetraploid, but sequential carcinogen treatment (diethylnitrosamine/2-acetylaminofluorene) induces the development of a predominantly diploid hepatocyte population. By two-parametric flow cytometry (simultaneous measurement of DNA and protein content within the same cell) it could be shown that diploid hepatocytes from carcinogen-treated rats had only half the size (protein content) of the tetraploid cells from the same liver, but the same size as diploid hepatocytes from normal rats.Entities:
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Year: 1986 PMID： 3943139 DOI： 10.1093/carcin/7.1.171
Source DB: PubMed Journal: Carcinogenesis ISSN： 0143-3334 Impact factor: 4.944