Translocation (19;?) in two stage II neuroblastomas.

Chromosomes of two abdominal neuroblastomas (stage II) from a 10-month-old male infant and a 6-year-old girl were analyzed. A modal chromosome number of 70 and 46, respectively, was found. Neither double minute chromosomes (DM) or homogeneously staining regions (HSR), nor visible structural abnormalities of chromosome #1 could be detected. However, a common aberration was found to be a translocation on the short arm of chromosome #19. After tumor resection, both children are alive without any evidence of tumor disease.