Literature DB >> 3941323

Chloroquine reduces neuronal and glial iron uptake.

K F Swaiman, V L Machen.   

Abstract

The effect of chloroquine, a lysosomotropic agent, on iron uptake into neuronal and glial cell cultures is reported. Chloroquine significantly inhibited iron uptake in both neuronal and glial cells. These findings suggest that iron transport into both neuronal and glial cells is mediated by the transferrin-iron complex.

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Year:  1986        PMID： 3941323     DOI： 10.1111/j.1471-4159.1986.tb13017.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  6 in total

1.  Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens.

Authors:  T F Byrd; M A Horwitz
Journal:  J Clin Invest       Date:  1991-07       Impact factor: 14.808

2.  Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae.

Authors:  Lyndal R Emerson; Martin E Nau; Rodger K Martin; Dennis E Kyle; Maryanne Vahey; Dyann F Wirth
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

Review 3.  Transferrin and transferrin receptor function in brain barrier systems.

Authors:  T Moos; E H Morgan
Journal:  Cell Mol Neurobiol       Date:  2000-02       Impact factor: 5.046

4.  Transferrin binding by mammalian cortical cells.

Authors:  K F Swaiman; V L Machen
Journal:  Neurochem Res       Date:  1986-09       Impact factor: 3.996

5.  Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis.

Authors:  S L Newman; L Gootee; G Brunner; G S Deepe
Journal:  J Clin Invest       Date:  1994-04       Impact factor: 14.808

6.  Inhibition of growth of Histoplasma capsulatum yeast cells in human macrophages by the iron chelator VUF 8514 and comparison of VUF 8514 with deferoxamine.

Authors:  S L Newman; L Gootee; V Stroobant; H van der Goot; J R Boelaert
Journal:  Antimicrob Agents Chemother       Date:  1995-08       Impact factor: 5.191
  6 in total

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