Literature DB >> 3940883

Sugar transport in Trypanosoma brucei: a suitable kinetic probe.

S Game, G Holman, R Eisenthal.   

Abstract

A transport assay has been developed for use in the investigation of 1-deoxy-D-glucose uptake in trypanosomes. 1-Deoxy-D-glucose has high affinity for the trypanosome sugar transport system (net influx Km = 4.03 +/- 0.42 mM; V = 0.052 +/- 0.005 mM X s-1. D-Glucose oxidation is competitively inhibited by 1-deoxy-D-glucose. However, we show that 1-deoxy-D-glucose is not a substrate for metabolism and that the competition occurs because of interaction at the transport system. D-Glucose competitively inhibits 1-deoxy-D-glucose influx.

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Year:  1986        PMID： 3940883     DOI： 10.1016/0014-5793(86)80063-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Differential regulation of two distinct families of glucose transporter genes in Trypanosoma brucei.

Authors:  F Bringaud; T Baltz
Journal:  Mol Cell Biol       Date:  1993-02       Impact factor: 4.272

2.  Comparative physiology of two protozoan parasites, Leishmania donovani and Trypanosoma brucei, grown in chemostats.

Authors:  B H ter Kuile; F R Opperdoes
Journal:  J Bacteriol       Date:  1992-05       Impact factor: 3.490

Review 3.  Treg cell-based therapies: challenges and perspectives.

Authors:  Caroline Raffin; Linda T Vo; Jeffrey A Bluestone
Journal:  Nat Rev Immunol       Date:  2019-12-06       Impact factor: 53.106

4.  Dihydrolipoamide dehydrogenase from Trypanosoma brucei. Characterization and cellular location.

Authors:  M J Danson; K Conroy; A McQuattie; K J Stevenson
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

5.  Mutual adjustment of glucose uptake and metabolism in Trypanosoma brucei grown in a chemostat.

Authors:  B H ter Kuile; F R Opperdoes
Journal:  J Bacteriol       Date:  1992-02       Impact factor: 3.490
  5 in total

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