Literature DB >> 3940815

Lethal enhancement of therapeutic doses of acetaminophen by alcohol.

P B Lesser, M M Vietti, W D Clark.   

Abstract

A 47-year-old man undergoing supervised alcohol detoxification developed severe liver disease after receiving small doses of acetaminophen. Autopsy revealed extensive hepatic necrosis. Proposed mechanisms for alcohol potentiation of acetaminophen hepatotoxicity are described. We feel acetaminophen should not be routinely used for patients with active alcoholism unless its safety can be established.

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Year:  1986        PMID： 3940815     DOI： 10.1007/bf01347918

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  13 in total

Review 1.  Acetaminophen hepatotoxicity.

Authors:  M Black
Journal:  Gastroenterology       Date:  1980-02       Impact factor: 22.682

2.  Apparent potentiation of acetaminophen hepatotoxicity by alcohol.

Authors:  H Licht; L B Seeff; H J Zimmerman
Journal:  Ann Intern Med       Date:  1980-04       Impact factor: 25.391

3.  Hepatocytoprotective substances.

Authors:  R F Burk
Journal:  Gastroenterology       Date:  1981-08       Impact factor: 22.682

4.  Concomitant alcohol and drug abuse enhancing acetaminophen toxicity. Report of a case.

Authors:  R Goldfinger; K S Ahmed; C S Pitchumoni; S A Weseley
Journal:  Am J Gastroenterol       Date:  1978-10       Impact factor: 10.864

5.  Ethanol induction of acetaminophen toxicity and metabolism.

Authors:  F J Peterson; D E Holloway; R R Erickson; P H Duquette; C J McClain; J L Holtzman
Journal:  Life Sci       Date:  1980-11-03       Impact factor: 5.037

6.  Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat.

Authors:  C Sato; Y Matsuda; C S Lieber
Journal:  Gastroenterology       Date:  1981-01       Impact factor: 22.682

7.  Prevention of acetaminophen-induced hepatotoxicity by acute ethanol administration in the rat: comparison with carbon tetrachloride-induced hepatoxicity.

Authors:  C Sato; M Nakano; C S Lieber
Journal:  J Pharmacol Exp Ther       Date:  1981-09       Impact factor: 4.030

8.  Potentiation of acetaminophen hepatotoxicity by alcohol.

Authors:  C J McClain; J P Kromhout; F J Peterson; J L Holtzman
Journal:  JAMA       Date:  1980-07-18       Impact factor: 56.272

9.  Treatment of acetaminophen poisoning. The use of oral methionine.

Authors:  J A Vale; T J Meredith; R Goulding
Journal:  Arch Intern Med       Date:  1981-02-23

10.  Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.

Authors:  D J Emby; B N Fraser
Journal:  S Afr Med J       Date:  1977-02-12
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  6 in total

1.  Acetaminophen and alcoholics.

Authors:  A H Hall; K W Kulig; B H Rumack
Journal:  Dig Dis Sci       Date:  1987-05       Impact factor: 3.199

Review 2.  Assessing the autopsy.

Authors:  P N Nemetz; J Ludwig; L T Kurland
Journal:  Am J Pathol       Date:  1987-08       Impact factor: 4.307

Review 3.  Paracetamol, alcohol and the liver.

Authors:  L F Prescott
Journal:  Br J Clin Pharmacol       Date:  2000-04       Impact factor: 4.335

4.  Analgesics in patients with hepatic impairment: pharmacology and clinical implications.

Authors:  Marija Bosilkovska; Bernhard Walder; Marie Besson; Youssef Daali; Jules Desmeules
Journal:  Drugs       Date:  2012-08-20       Impact factor: 9.546

5.  Light to moderate drinking and therapeutic doses of acetaminophen: An assessment of risks for renal dysfunction.

Authors:  Harrison Ndetan; Marion W Evans; Ashwani K Singal; Lane J Brunner; Kirk Calhoun; Karan P Singh
Journal:  Prev Med Rep       Date:  2018-10-24

Review 6.  Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature.

Authors:  Thomas M Caparrotta; Daniel J Antoine; James W Dear
Journal:  Eur J Clin Pharmacol       Date:  2017-10-24       Impact factor: 2.953
  6 in total

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