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Literature DB >> 393993

Fatty acid alpha-hydroxylation and its relation to myelination.

Abstract

alpha-Hydroxylation is an enzymatic reaction by which long-chain fatty acids are converted to their alpha-hydroxy derivatives. This reaction, in animals, can be detected only in developing brain and is the rate-determining step in the synthesis of hydroxycerebroside, which is an indispensable and abundant myelin lipid. In addition to a particulate fraction from brain, two cytoplasmic factors, one heat-stable and the other heat-labile, are required for alpha-hydroxylation. During the past eight years we have been investigating alpha-hydroxylation. Our progress is summarized and discussed here.

Entities: Chemical

Mesh：

Substances：

Year: 1979 PMID： 393993 DOI： 10.1007/bf00223361

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

45 in total

1. ISOTOPIC STUDIES OF THE BIOSYNTHESIS OF THE CEREBROSIDE FATTY ACIDS IN RATS.

Authors: A K HAJRA; N S RADIN
Journal: J Lipid Res Date: 1963-07 Impact factor: 5.922

2. alpha-Hydroxylation of fatty acids in brain. Substrate specificity and deuterium isotope effect.

Authors: S Murad; R H Chen; Y Kishimoto
Journal: J Biol Chem Date: 1977-08-10 Impact factor: 5.157

3. Fat metabolism in higher plants. Recent studies on plant alpha-oxidation systems.

Authors: W E Shine; P K Stumpf
Journal: Arch Biochem Biophys Date: 1974-05 Impact factor: 4.013

4. Alpha-oxidation of 2-hydroxystearic acid in vitro.

Authors: K Lippel; J F Mead
Journal: Biochim Biophys Acta Date: 1968-07-01

5. Alpha oxidation of cerebronic acid in brains from scorbutic and ascorbic acid-supplemented guinea pigs.

Authors: J F Mead; R S Hare
Journal: Biochem Biophys Res Commun Date: 1971-12-17 Impact factor: 3.575

6. The stereochemistry of alpha-oxidation of fatty acids in plants. Isotope competition experiments.

Authors: C Hitchcock; L J Morris; A T James
Journal: Eur J Biochem Date: 1968-02

7. Alpha-oxidation of 2-hydroxy tetracosanoate in the rat.

Authors: K Lippel; J F Mead
Journal: Lipids Date: 1969-03 Impact factor: 1.880

8. Enzymatic hydrolysis of sphingolipids. 8. Further purification and properties of rat brain ceramidase.

Authors: E Yavin; S Gatt
Journal: Biochemistry Date: 1969-04 Impact factor: 3.162

9. The mechanism of alpha-oxidation in leaves.

Authors: C Hitchcock; A T James
Journal: Biochim Biophys Acta Date: 1966-06-01

10. Alpha-Hydroxylation of lignoceric and nervonic acids in the brain. Effects of altered thyroid function on postnatal development of the hydroxylase activity.

Authors: S Murad; G D Strycharz; Y Kishimoto
Journal: J Biol Chem Date: 1976-09-10 Impact factor: 5.157

9 in total

Fatty acid alpha-hydroxylation and its relation to myelination.

1. ISOTOPIC STUDIES OF THE BIOSYNTHESIS OF THE CEREBROSIDE FATTY ACIDS IN RATS.

2. alpha-Hydroxylation of fatty acids in brain. Substrate specificity and deuterium isotope effect.

3. Fat metabolism in higher plants. Recent studies on plant alpha-oxidation systems.

4. Alpha-oxidation of 2-hydroxystearic acid in vitro.

5. Alpha oxidation of cerebronic acid in brains from scorbutic and ascorbic acid-supplemented guinea pigs.

6. The stereochemistry of alpha-oxidation of fatty acids in plants. Isotope competition experiments.

7. Alpha-oxidation of 2-hydroxy tetracosanoate in the rat.

8. Enzymatic hydrolysis of sphingolipids. 8. Further purification and properties of rat brain ceramidase.

9. The mechanism of alpha-oxidation in leaves.

10. Alpha-Hydroxylation of lignoceric and nervonic acids in the brain. Effects of altered thyroid function on postnatal development of the hydroxylase activity.

Review 1. Fatty acid 2-Hydroxylation in mammalian sphingolipid biology.

2. Identification of the pathway of alpha-oxidation of cerebronic acid in peroxisomes.

3. Synthesis of non-hydroxy-galactosylceramides and galactosyldiglycerides by hydroxy-ceramide galactosyltransferase.

Review 4. Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism.

5. Myelin lipids: a phylogenetic study.

6. Alpha-hydroxylation and oxidation of lignoceric acid in brain: the role of heat-stable and heat-labile factors.

7. Triethyllead treatment of cultured brain cells. Effect on accumulation of radioactive precursors in galactolipids.

8. FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin.

9. Proteomic signature of muscle fibre hyperplasia in response to faba bean intake in grass carp.