Literature DB >> 393929

The effects of the hypocholesteremic compound 3 beta-(beta-dimethylaminoethoxy)-androst-5-en-17-one on the sterol and steryl ester composition of Saccharomyces cerevisiae.

R B Field, C E Holmlund, N F Whittaker.   

Abstract

When yeast was grown in the presence of 10(-4) M 3 beta-(beta-dimethylaminoethoxy)-androst-5-en-17-one (DMAE-DHA), the compound 2,3;22,23-dioxidosqualene (DOS) accumulated. Total free sterol was reduced by about 30%, whereas almost no steryl esters were found. The same drug at lower concentration (3 x 10(-6) M) caused a slight increase in steryl ester production, and a 24% reduction in free sterol content. The marked accumulation of ergostra-5,7,22,24(28)-tetraen-3 beta-ol with 3 x 10(-6) M DMAE-DHA indicated that the C24-28 reductase is especially sensitive to the action of the drug.

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Year:  1979        PMID： 393929     DOI： 10.1007/bf02533900

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  14 in total

1.  Studies of cholesterol biosynthesis. IV. Reduction of lanosterol to 24,25-dihydrolanosterol by rat liver homogenates.

Authors:  J AVIGAN; D S GOODMAN; D STEINBERG
Journal:  J Biol Chem       Date:  1963-04       Impact factor: 5.157

2.  Inhibtion of diplopterol synthesis in Tetrahymena pyriformis by a hypocholesteremic compound.

Authors:  Z Babiak; T L Carlisle; C E Holmlund
Journal:  Lipids       Date:  1975-07       Impact factor: 1.880

3.  Extraction of lipids from yeast.

Authors:  M T Sobus; C E Homlund
Journal:  Lipids       Date:  1976-04       Impact factor: 1.880

4.  The effect of triparanol on the composition of free and esterified sterols of Saccharomyces cerevisiae.

Authors:  C Campagnoni; C E Holmlund; N Whittaker
Journal:  Arch Biochem Biophys       Date:  1977-12       Impact factor: 4.013

5.  Isolation of 2,3;22,23-dioxidosqualene and 24,25-oxidolanosterol from yeast.

Authors:  R B Field; C E Holmlund
Journal:  Arch Biochem Biophys       Date:  1977-04-30       Impact factor: 4.013

6.  Biosynthesis of ergosterol in yeast. Evidence for multiple pathways.

Authors:  M Fryberg; A C Oehlschlager; A M Unrau
Journal:  J Am Chem Soc       Date:  1973-08-22       Impact factor: 15.419

7.  A comparison of the effects of some hypocholesteremic compounds on squalene metabolism in Tetrahymena pyriformis and rat liver.

Authors:  J D Sipe; C E Holmlund
Journal:  Biochim Biophys Acta       Date:  1972-09-07

8.  Effects of a vertebrate hypocholesterolemic agent on sterol metabolism and development of Bombyx mori.

Authors:  H Hikino; Y Oizumi; T Saito; E Nakamura; T Takemoto
Journal:  Chem Pharm Bull (Tokyo)       Date:  1972-04       Impact factor: 1.645

9.  [Delta-24(28)-dehydro-erogsterin, isolation and chemical reactions].

Authors:  K Petzoldt; M Kühne; E Blanke; K Kieslich; E Kaspar
Journal:  Justus Liebigs Ann Chem       Date:  1967

10.  Effects of the hypocholesteremic agent trifluperidol on the sterol, steryl ester, and fatty acid metabolism of Saccharomyces cerevisiae.

Authors:  M T Sobus; C E Holmlund; N F Whittaker
Journal:  J Bacteriol       Date:  1977-06       Impact factor: 3.490
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  5 in total

1.  Synthesis and biological activity of new iodoacetamide derivatives on mutants of squalene-hopene cyclase.

Authors:  Maurizio Ceruti; Gianni Balliano; Flavio Rocco; Alexander Lenhart; Georg E Schulz; Francesco Castelli; Paola Milla
Journal:  Lipids       Date:  2005-07       Impact factor: 1.880

2.  Umbelliferone aminoalkyl derivatives as inhibitors of oxidosqualene cyclases from Saccharomyces cerevisiae, Trypanosoma cruzi, and Pneumocystis carinii.

Authors:  Simonetta Oliaro-Bosso; Franca Viola; Seiichi Matsuda; Giancarlo Cravotto; Silvia Tagliapietra; Gianni Balliano
Journal:  Lipids       Date:  2004-10       Impact factor: 1.880

3.  The effect of AY-9944 on yeast sterol and sterol ester metabolism.

Authors:  R Pereira; C E Holmlund; N Whittaker
Journal:  Lipids       Date:  1983-08       Impact factor: 1.880

4.  Analogs of squalene and oxidosqualene inhibit oxidosqualene cyclase of Trypanosoma cruzi expressed in Saccharomyces cerevisiae.

Authors:  Simonetta Oliaro-Bosso; Maurizio Ceruti; Gianni Balliano; Paola Milla; Flavio Rocco; Franca Viola
Journal:  Lipids       Date:  2005-12       Impact factor: 1.880

5.  Characterization of the channel constriction allowing the access of the substrate to the active site of yeast oxidosqualene cyclase.

Authors:  Simonetta Oliaro-Bosso; Giulia Caron; Silvia Taramino; Giuseppe Ermondi; Franca Viola; Gianni Balliano
Journal:  PLoS One       Date:  2011-07-21       Impact factor: 3.240
  5 in total

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