[Significance of urothelial dysplasia in macroscopically normal mucosa in patients with bladder tumors. Results of a randomized study with and without intravesical mitomycin C in the prevention of recurrence].

During endoscopic treatment of 90 patients with bladder tumors, multiple random biopsies were carried out on normal looking bladder mucosa. Dysplasias were found in 25.6% of the patients. These findings are almost identical to the results of histological examination of bladder in autopsies. Postoperatively, a randomized prophylactic Mitomycin instillation therapy was carried out. Although the recurrence rate under Mitomycin treatment was significantly lower here than in the control group (18.8% vs. 56.7%), the rate of dysplasias was nearly twice as high as in the control group (43.8% vs. 23.3%). Therefore, the conclusion can be drawn that dysplasia only reflects the present picture of proliferative activity of urothelium, but allows no interpretation of biological activity or prognosis of bladder carcinoma.

RCT Entities:   Population Interventions Outcomes