Literature DB >> 3936656

Interferon induces proliferation and differentiation in primary chronic lymphocytic leukaemia cells.

K H Robert, S Einhorn, G Juliusson, L Ostlund, P Biberfeld.   

Abstract

The influence of interferon-alpha (IFN-alpha) on the differentiation of malignant cells from six patients with chronic lymphocytic leukaemia was studied in vitro. IFN induced differentiation in the leukaemic cells from four of the patients. In cells from two of these patients, IFN also induced proliferation. When tested by immunofluorescence, the clonality of the differentiating cells was established by the presence of intracellular light chains of one type only.

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Year:  1985        PMID： 3936656      PMCID： PMC1577457     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  11 in total

1.  Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells.

Authors:  K PAUCKER; K CANTELL; W HENLE
Journal:  Virology       Date:  1962-06       Impact factor: 3.616

2.  Large-scale production of human leukocyte interferon containing 10(8) units per ml.

Authors:  K Cantell; S Hirvonen
Journal:  J Gen Virol       Date:  1978-06       Impact factor: 3.891

Review 3.  Induction of monoclonal antibody synthesis in malignant human B cells by polyclonal B cell activators. Relationship between B cell subsets and prognosis.

Authors:  K H Robèrt
Journal:  Immunol Rev       Date:  1979       Impact factor: 12.988

4.  Preliminary observations on the effect of human leukocyte interferon in non-Hodgkin's lymphoma.

Authors:  T C Merigan; K Sikora; J H Breeden; R Levy; S A Rosenberg
Journal:  N Engl J Med       Date:  1978-12-28       Impact factor: 91.245

5.  Stimulation by interferon of induction of differentiation of mouse myeloid leukemic cells.

Authors:  M Tomida; Y Yamamoto; M Hozumi
Journal:  Cancer Res       Date:  1980-08       Impact factor: 12.701

6.  Interactions of interferon with in vitro model systems involved in hematopoietic cell differentiation.

Authors:  G B Rossi; A Dolei; M R Capobianchi; C Peschle; E Affabris
Journal:  Ann N Y Acad Sci       Date:  1980       Impact factor: 5.691

7.  B-cell activation of peripheral blood lymphocytes from patients with chronic lymphatic leukaemia.

Authors:  K H Robèrt; E Möller; G Gahrton; H Eriksson; B Nilsson
Journal:  Clin Exp Immunol       Date:  1978-08       Impact factor: 4.330

8.  Influence of interferon on poke weed mitogen triggered Ig-secretion by human lymphocytes in vitro.

Authors:  H Blomgren; S Einhorn; L V Von Stedingk; J Wasserman
Journal:  J Interferon Res       Date:  1981

9.  Interferon in cancer: Faith, hope and reality.

Authors:  H Strander; S Einhorn
Journal:  Am J Clin Oncol       Date:  1982-06       Impact factor: 2.339

10.  Interferon therapy in myelomatosis.

Authors:  H Mellstedt; A Ahre; M Björkholm; G Holm; B Johansson; H Strander
Journal:  Lancet       Date:  1979-02-03       Impact factor: 79.321
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