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Literature DB >> 3934641

Hyperpolarizing membrane potential changes in a cloned monkey kidney cell line.

H Chang, N Yamashita, E Ogata, K Kurokawa.

Abstract

Electrophysiological properties of a cloned monkey kidney cell line, JTC-12, were studied. The mean resting potential and input resistance were -15.3 mV and 78 M omega, respectively. Spontaneous hyperpolarizations with increased membrane conductance were observed. Similar hyperpolarization could be elicited by mechanical and electrical stimulations. The mean reversal potential of these hyperpolarizations was -72.7 mV. Hyperpolarization could be also elicited in a chloride-free solution. These data indicate that: JTC-12 cells exhibit spontaneous and induced hyperpolarizations, and occurrence of hyperpolarization is related to an increase in membrane permeability to potassium ions.

Entities: Chemical

Mesh：

Substances：
Potassium

Year: 1985 PMID： 3934641 DOI： 10.1007/bf00582564

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

24 in total

Review 1. Studies of renal cell function using cell culture techniques.

Authors: J S Handler; F M Perkins; J P Johnson
Journal: Am J Physiol Date: 1980-01

2. Oscillations of membrane potential in L cells. I. Basic characteristics.

Authors: Y Okada; Y Doida; G Roy; W Tsuchiya; K Inouye; A Inouye
Journal: J Membr Biol Date: 1977-08-04 Impact factor: 1.843

3. Regulation of 24,25-dihydroxyvitamin D-3 production by 1,25-dihydroxyvitamin D-3 and synthetic human parathyroid hormone fragment 1-34 in a cloned monkey kidney cell line (JTC-12).

Authors: T Matsumoto; Y Kawanobe; E Ogata
Journal: Biochim Biophys Acta Date: 1985-06-30

4. Characterization of apical cell membrane Na+ and K+ conductances of cortical collecting duct using microelectrode techniques.

Authors: R G O'Neil; S C Sansom
Journal: Am J Physiol Date: 1984-07

Hyperpolarizing membrane potential changes in a cloned monkey kidney cell line.

Review 1. Studies of renal cell function using cell culture techniques.

2. Oscillations of membrane potential in L cells. I. Basic characteristics.

3. Regulation of 24,25-dihydroxyvitamin D-3 production by 1,25-dihydroxyvitamin D-3 and synthetic human parathyroid hormone fragment 1-34 in a cloned monkey kidney cell line (JTC-12).

4. Characterization of apical cell membrane Na+ and K+ conductances of cortical collecting duct using microelectrode techniques.

5. Intracellular potassium activity in the rabbit proximal straight tubule.

6. Periodic hyperpolarizing responses in hamster and mouse eggs fertilized with mouse sperm.

7. Fertilization potential in golden hamster eggs consists of recurring hyperpolarizations.

8. Membrane potential oscillations in homokaryons. An endogenous signal for detecting intercellular communication.

9. Effects of cytochalasin B and local anesthetics on electrical and morphological properties in L cells.

10. Interaction of chemotactic factors with human macrophages. Induction of transmembrane potential changes.

1. Ca2+-activated K+ conductance causes membrane hyperpolarizations in a monkey kidney cell line (JTC-12).