Literature DB >> 3934564

Vernolepin: an antiplatelet compound of natural origin.

G M Laekeman, F De Clerck, A J Vlietinck, A G Herman.   

Abstract

Vernolepin, a natural compound isolated from Vernonia amygdalina Del., shows platelet anti-aggregating properties. In this paper some of its pharmacological activities towards rabbit platelets are studied. Vernolepin has a "stabilizing" effect during freeze-thawing of platelets, it inhibits arachidonic acid, ADP and collagen-induced platelet aggregation and interferes with ATP-release. Electromicroscopy shows a protection of platelets by the drug against adhesion and a desaggregating effect. All these activities are time dependent; a steep dose response relationship is seen. A concentration of 1 X 10(-5) g/ml seems to be optimal.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3934564     DOI： 10.1007/bf00498859

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  6 in total

1.  Aggregation of blood platelets by adenosine diphosphate and its reversal.

Authors:  G V BORN
Journal:  Nature       Date:  1962-06-09       Impact factor: 49.962

2.  Inhibition and reversal of platelet activation by cytochalasin B or colcemid.

Authors:  M M Boyle Kay; H H Fudenberg
Journal:  Nature       Date:  1973-08-03       Impact factor: 49.962

3.  Determination of ATP and ADP in blood platelets: a modification of the firefly luciferase assay for plasma.

Authors:  H Holmsen; E Storm; H J Day
Journal:  Anal Biochem       Date:  1972-04       Impact factor: 3.365

4.  Human platelet aggregation by Thrombofax. An electron-microscopic study of the sequence of events.

Authors:  F de Clerck; M Borgers; J Vermylen; G de Gaetano
Journal:  Scand J Haematol       Date:  1974

5.  Tumor inhibitors. XLVI. Vernolepin, a novel sesquiterpene dilactone tumor inhibitor from Vernonia hymenolepis A. Rich.

Authors:  S M Kupchan; R J Hemingway; D Werner; A Karim
Journal:  J Org Chem       Date:  1969-12       Impact factor: 4.354

6.  Isolation and pharmacological characterization of vernolepin.

Authors:  G M Laekeman; J Mertens; J Totté; H Bult; A J Vlietinck; A G Herman
Journal:  J Nat Prod       Date:  1983 Mar-Apr       Impact factor: 4.050
  6 in total
  3 in total

1.  Cytotoxic sesquiterpene lactones from the leaves of Vernonia guineensis Benth. (Asteraceae).

Authors:  Ngeh J Toyang; Hippolyte K Wabo; Eugene N Ateh; Harry Davis; Pierre Tane; Luc B Sondengam; Joseph Bryant; Rob Verpoorte
Journal:  J Ethnopharmacol       Date:  2013-01-30       Impact factor: 4.360

2.  Cytotoxic and other bioactivities of a novel and known sesquiterpene lactones isolated from Vernonia leopoldi (Sch. Bip. ex Walp.) Vatke in breast cancer cell lines.

Authors:  Nigatu Tuasha; Zilma Escobar; Daniel Seifu; Endalamaw Gadisa; Beyene Petros; Olov Sterner; Stina Oredsson
Journal:  Toxicol Rep       Date:  2022-03-06

3.  JAK2/STAT3‑mediated dose‑dependent cytostatic and cytotoxic effects of sesquiterpene lactones from Gymnanthemum extensum on A549 human lung carcinoma cells.

Authors:  Siriporn Keeratichamroen; Kriengsak Lirdprapamongkol; Sanit Thongnest; Jutatip Boonsombat; Pornsuda Chawengrum; Thiwaree Sornprachum; Jitnapa Sirirak; Chris Verathamjamras; Narittira Ornnork; Somsak Ruchirawat; Jisnuson Svasti
Journal:  Oncol Rep       Date:  2021-11-05       Impact factor: 3.906
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.