Literature DB >> 3934003

Inhibition of 5-lipoxygenase by vitamin E.

P Reddanna, M K Rao, C C Reddy.   

Abstract

Purified 5-lipoxygenase from potato tubers was inhibited strongly by vitamin E and its analogs. The inhibition by d-alpha-tocopherol was found to be irreversible and non-competitive with respect to arachidonic acid. An IC50 of 5 microM was calculated for d-alpha-tocopherol. The inhibition appears to be unrelated to its antioxidant function. Binding studies with 14C-labelled d-alpha-tocopherol revealed that there is a strong interaction between vitamin E and 5-lipoxygenase. Tryptic digestion and peptide mapping of 5-lipoxygenase-vitamin E complex indicate that vitamin E binds strongly to a single peptide. These studies suggest that cellular vitamin E levels may have profound influence on the formation of leukotrienes.

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Year:  1985        PMID： 3934003     DOI： 10.1016/0014-5793(85)80075-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  29 in total

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Authors:  M J Jackson; A J Wagenmakers; R H Edwards
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4.  Putative analgesic activity of repeated oral doses of vitamin E in the treatment of rheumatoid arthritis. Results of a prospective placebo controlled double blind trial.

Authors:  S E Edmonds; P G Winyard; R Guo; B Kidd; P Merry; A Langrish-Smith; C Hansen; S Ramm; D R Blake
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5.  Dietary supplementation of vitamin E protects heart tissue from exercise-induced oxidant stress.

Authors:  C T Kumar; V K Reddy; M Prasad; K Thyagaraju; P Reddanna
Journal:  Mol Cell Biochem       Date:  1992-04       Impact factor: 3.396

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7.  Ascorbic acid, glutathione and synthetic antioxidants prevent the oxidation of vitamin E in platelets.

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8.  Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase.

Authors:  A M Schaible; R Filosa; V Temml; V Krauth; M Matteis; A Peduto; F Bruno; S Luderer; F Roviezzo; A Di Mola; M de Rosa; B D'Agostino; C Weinigel; D Barz; A Koeberle; C Pergola; D Schuster; O Werz
Journal:  Br J Pharmacol       Date:  2014-05       Impact factor: 8.739

9.  Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration.

Authors:  Savita Khanna; Sashwati Roy; Hoon Ryu; Praveen Bahadduri; Peter W Swaan; Rajiv R Ratan; Chandan K Sen
Journal:  J Biol Chem       Date:  2003-08-13       Impact factor: 5.157

10.  Homology modeling of 5-lipoxygenase and hints for better inhibitor design.

Authors:  P Aparoy; R N Reddy; Lalitha Guruprasad; M R Reddy; P Reddanna
Journal:  J Comput Aided Mol Des       Date:  2008-01-30       Impact factor: 3.686
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