| Literature DB >> 39340 |
F Guerrero-Munoz, M de Lourdes Guerrero, E L Way, C H Li.
Abstract
The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.Entities:
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Year: 1979 PMID： 39340 DOI： 10.1126/science.39340
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728