Literature DB >> 3932821

Viability of Escherichia coli K-12 DNA adenine methylase (dam) mutants requires increased expression of specific genes in the SOS regulon.

K R Peterson, K F Wertman, D W Mount, M G Marinus.   

Abstract

We have examined the level of expression of the SOS regulon in cells lacking DNA adenine methylase activity (dam-). Mud (Ap, lac) fusions to several SOS operons (recA, lexA, uvrA, uvrB, uvrD, sulA, dinD and dinF) were found to express higher levels of beta-galactosidase in dam- strains than in isogenic dam+ strains. The attempted construction of dam- strains that were also mutant in one of several SOS genes indicated that the viability of methylase-deficient strains correlates with the inactivation of the SOS repressor (LexA protein). Consistent with this, the wild-type functions of two LexA-repressed genes (recA and ruv) appear to be required for dam- strain viability.

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Year:  1985        PMID： 3932821     DOI： 10.1007/bf00397979

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  66 in total

1.  The effect of lexA and recF mutations on post-replication repair and DNA synthesis in Escherichia coli K-12.

Authors:  A K Ganesan; P C Seawell
Journal:  Mol Gen Genet       Date:  1975-12-01

2.  Dual role for Escherichia coli RecA protein in SOS mutagenesis.

Authors:  D G Ennis; B Fisher; S Edmiston; D W Mount
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

3.  [Prophage induction and cell division in E. coli. II. Linked (recA, zab) and unlinked (lex) suppressors of tif-1-mediated induction and filamentation].

Authors:  M Castellazzi; J George; G Buttin
Journal:  Mol Gen Genet       Date:  1972

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Authors:  E M Witkin
Journal:  Bacteriol Rev       Date:  1976-12

5.  Repair of DNA double-strand breaks in Escherichia coli K12 requires a functional recN product.

Authors:  S M Picksley; P V Attfield; R G Lloyd
Journal:  Mol Gen Genet       Date:  1984

6.  Mu dX, a derivative of Mu d1 (lac Apr) which makes stable lacZ fusions at high temperature.

Authors:  T A Baker; M M Howe; C A Gross
Journal:  J Bacteriol       Date:  1983-11       Impact factor: 3.490

7.  Insertion mutations in the dam gene of Escherichia coli K-12.

Authors:  M G Marinus; M Carraway; A Z Frey; L Brown; J A Arraj
Journal:  Mol Gen Genet       Date:  1983

8.  Genetic analysis of the recJ gene of Escherichia coli K-12.

Authors:  S T Lovett; A J Clark
Journal:  J Bacteriol       Date:  1984-01       Impact factor: 3.490

9.  Characterisation of the promoter for the LexA regulated sulA gene of Escherichia coli.

Authors:  S T Cole
Journal:  Mol Gen Genet       Date:  1983

10.  Cleavage of the Escherichia coli lexA protein by the recA protease.

Authors:  J W Little; S H Edmiston; L Z Pacelli; D W Mount
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205
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  42 in total

1.  Recombination is essential for viability of an Escherichia coli dam (DNA adenine methyltransferase) mutant.

Authors:  M G Marinus
Journal:  J Bacteriol       Date:  2000-01       Impact factor: 3.490

Review 2.  Roles of DNA adenine methylation in regulating bacterial gene expression and virulence.

Authors:  D A Low; N J Weyand; M J Mahan
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

3.  Role of SeqA and Dam in Escherichia coli gene expression: a global/microarray analysis.

Authors:  Anders Løbner-Olesen; Martin G Marinus; Flemming G Hansen
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-07       Impact factor: 11.205

Review 4.  Biological function of DNA methylation.

Authors:  J Hubácek
Journal:  Folia Microbiol (Praha)       Date:  1992       Impact factor: 2.099

5.  Isolation of SOS constitutive mutants of Escherichia coli.

Authors:  Erin K O'Reilly; Kenneth N Kreuzer
Journal:  J Bacteriol       Date:  2004-11       Impact factor: 3.490

6.  Chromosome partitioning in Escherichia coli in the absence of dam-directed methylation.

Authors:  D Vinella; A Jaffé; R D'Ari; M Kohiyama; P Hughes
Journal:  J Bacteriol       Date:  1992-04       Impact factor: 3.490

7.  Genetic evidence for the requirement of RecA loading activity in SOS induction after UV irradiation in Escherichia coli.

Authors:  Ivana Ivancic-Bace; Ignacija Vlasic; Erika Salaj-Smic; Krunoslav Brcic-Kostic
Journal:  J Bacteriol       Date:  2006-07       Impact factor: 3.490

8.  Roles of PriA protein and double-strand DNA break repair functions in UV-induced restriction alleviation in Escherichia coli.

Authors:  Ivana Ivancić-Bacće; Ignacija Vlasić; Gordana Cogelja-Cajo; Krunoslav Brcić-Kostić; Erika Salaj-Smic
Journal:  Genetics       Date:  2006-10-08       Impact factor: 4.562

9.  Bile-induced DNA damage in Salmonella enterica.

Authors:  Ana I Prieto; Francisco Ramos-Morales; Josep Casadesús
Journal:  Genetics       Date:  2004-12       Impact factor: 4.562

10.  Dam methyltransferase is required for stable lysogeny of the Shiga toxin (Stx2)-encoding bacteriophage 933W of enterohemorrhagic Escherichia coli O157:H7.

Authors:  Kenan C Murphy; Jennifer M Ritchie; Matthew K Waldor; Anders Løbner-Olesen; M G Marinus
Journal:  J Bacteriol       Date:  2007-11-02       Impact factor: 3.490
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