| Literature DB >> 3932582 |
E S Vitetta, J Ohara, C D Myers, J E Layton, P H Krammer, W E Paul.
Abstract
By three criteria, we have demonstrated that B cell stimulatory factor (BSF-1) and B cell differentiation factor (BCDF-gamma) are the same lymphokine. Highly purified preparations of high performance liquid chromatography-purified or affinity-purified BSF-1 had BCDF-gamma activity but not BCDF-mu activity. A monoclonal anti-BSF-1 antibody coupled to Sepharose depleted both BSF-1 and BCDF-gamma activity but not BCDF-mu activity from two different T cell supernatants. Soluble monoclonal anti-BSF-1 blocked the BSF-1 and BCDF-gamma but not the BCDF-mu responses. These results suggest that BSF-1 acts on both resting and activated B cells to induce different effects.Entities:
Mesh：
Substances：
Year: 1985 PMID： 3932582 PMCID： PMC2187936 DOI： 10.1084/jem.162.5.1726
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307