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Literature DB >> 3931225

Pharmacology of intraperitoneal infusion 5-fluorouracil and mitomycin-C.

Abstract

The pharmacokinetics of intraperitoneal infusion 5-fluorouracil and bolus administration mitomycin-C have been evaluated and permit one to determine the exposure advantage for this route of administration. as with other forms of regional chemotherapy, the limiting toxicity is locoregional. The therapeutic efficacy of this approach awaits the design and conduct of clinical trials.

Entities: Chemical Disease

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Year: 1985 PMID： 3931225

Source DB: PubMed Journal: Semin Oncol ISSN： 0093-7754 Impact factor: 4.929

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Cited

10 in total

1. Intraarterial hepatic chemotherapy with fluorouracil, fluorodeoxyuridine, mitomycin C, cisplatin or methotrexate as single-agent anticancer drugs for a transplanted experimental liver tumor in rats.

Authors: S Kurth; D Bulian; B Kreft; T Riemenschneider
Journal: J Cancer Res Clin Oncol Date: 1996 Impact factor: 4.553

2. Adjuvant intraperitoneal 5-fluorouracil in high-risk colon cancer: A multicenter phase III trial.

Authors: J C Vaillant; B Nordlinger; S Deuffic; J P Arnaud; E Pelissier; J P Favre; D Jaeck; G Fourtanier; J P Grandjean; P Marre; C Letoublon
Journal: Ann Surg Date: 2000-04 Impact factor: 12.969

3. Intraperitoneal 5-fluoro-2'-deoxyuridine with escalating doses of leucovorin: pharmacology and clinical tolerance.

Authors: F M Muggia; A Tulpule; A Retzios; F Chen; S Jeffers; C G Leichman; L Leichman; C P Spears; K K Chan
Journal: Invest New Drugs Date: 1994 Impact factor: 3.850

4. Early post-operative 5-fluorouracil does not affect the healing of experimental intestinal anastomoses.

Authors: J W de Waard; T Wobbes; T Hendriks
Journal: Int J Colorectal Dis Date: 1993-09 Impact factor: 2.571

5. Intraperitoneal 5-fluoro-2'-deoxyuridine (FUDR) and (S)-leucovorin for disease predominantly confined to the peritoneal cavity: a pharmacokinetic and toxicity study.

Authors: V K Israel; C Jiang; F M Muggia; A Tulpule; S Jeffers; L Leichman; C P Morrow; L Roman; C G Leichman; K K Chan
Journal: Cancer Chemother Pharmacol Date: 1995 Impact factor: 3.333

Pharmacology of intraperitoneal infusion 5-fluorouracil and mitomycin-C.

1. Intraarterial hepatic chemotherapy with fluorouracil, fluorodeoxyuridine, mitomycin C, cisplatin or methotrexate as single-agent anticancer drugs for a transplanted experimental liver tumor in rats.

2. Adjuvant intraperitoneal 5-fluorouracil in high-risk colon cancer: A multicenter phase III trial.

3. Intraperitoneal 5-fluoro-2'-deoxyuridine with escalating doses of leucovorin: pharmacology and clinical tolerance.

4. Early post-operative 5-fluorouracil does not affect the healing of experimental intestinal anastomoses.

5. Intraperitoneal 5-fluoro-2'-deoxyuridine (FUDR) and (S)-leucovorin for disease predominantly confined to the peritoneal cavity: a pharmacokinetic and toxicity study.

Review 6. Clinical pharmacology of 5-fluorouracil.

7. Phase I and pharmacologic evaluation of intraperitoneal 5-fluoro-2'-deoxyuridine.

Review 8. Intraperitoneal therapy in the management of ovarian carcinoma.

9. Intraperitoneal cytostatics impair healing of experimental intestinal anastomoses.

10. Clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer.