Literature DB >> 3931139

Ethanol inhibits the activity of the B form of monoamine oxidase in human platelet and brain tissue.

B Tabakoff, J M Lee, F De Leon-Jones, P L Hoffman.   

Abstract

Ethanol selectively inhibits the activity of the B-form of monoamine oxidase (MAO) in membranes obtained from human platelet and brain. When endogenous concentrations of phenylethylamine are used as substrate, significant inhibition is induced by concentrations of ethanol that are attainable after ethanol ingestion (50 mM). The mechanism of ethanol's inhibition of MAO activity appears to involve perturbation of membrane lipids surrounding the enzyme.

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Year:  1985        PMID： 3931139     DOI： 10.1007/bf00431799

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  32 in total

1.  A SENSITIVE AND SPECIFIC ASSAY FOR THE ESTIMATION OF MONOAMINE OXIDASE.

Authors:  R J WURTMAN; J AXELROD
Journal:  Biochem Pharmacol       Date:  1963-12       Impact factor: 5.858

2.  Substrate specificity of brain amine oxidase of several mammals.

Authors:  N WEINER
Journal:  Arch Biochem Biophys       Date:  1960-12       Impact factor: 4.013

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Authors:  F HEIM
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1950

4.  Evidence for a specific monoamine oxidase associated with sympathetic nerves.

Authors:  C Goridis; N H Neff
Journal:  Neuropharmacology       Date:  1971-09       Impact factor: 5.250

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Authors:  C M McEwen; G Sasaki; W R Lenz
Journal:  J Biol Chem       Date:  1968-10-25       Impact factor: 5.157

6.  Studies on monoamine oxidase. (Report XXV). Effects of alcohols on beef liver mitochondrial monoamine oxidase.

Authors:  Y Kurosawa
Journal:  Jpn J Pharmacol       Date:  1974-10

7.  Ethanol and the physical properties of brain membranes: fluorescence studies.

Authors:  R A Harris; F Schroeder
Journal:  Mol Pharmacol       Date:  1981-07       Impact factor: 4.436

8.  Rat liver mitochondrial monoamine oxidase. A change in the reaction mechanism on solubilization.

Authors:  M D Houslay; K F Tipton
Journal:  Biochem J       Date:  1975-02       Impact factor: 3.857

9.  Ontogeny of multiple forms of monoamine oxidase in mouse brain.

Authors:  F J Chordikian; B Tabakoff; S G Alivisatos
Journal:  Brain Res       Date:  1975-08-08       Impact factor: 3.252

10.  A relationship between alcohol intoxication and the disordering of brain membranes by a series of short-chain alcohols.

Authors:  R C Lyon; J A McComb; J Schreurs; D B Goldstein
Journal:  J Pharmacol Exp Ther       Date:  1981-09       Impact factor: 4.030
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  3 in total

1.  Potentiation by deprenyl of the autoreceptor-mediated inhibition of [3H]-5-hydroxytryptamine release by 5-methoxytryptamine.

Authors:  A M Galzin; S Z Langer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-07       Impact factor: 3.000

2.  Monoamine oxidase gene transcription in human cell lines: treatment with psychoactive drugs and ethanol.

Authors:  J Ekblom; Q S Zhu; K Chen; J C Shih
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

3.  Effects of beta-phenylethylamine on locomotor activity, body temperature and ethanol blood concentrations during acute ethanol intoxication.

Authors:  S U Aliyu; R D Sewell
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
  3 in total

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