Literature DB >> 3930990

Hormonal effects of high dose naloxone in humans.

M R Cohen, R M Cohen, D Pickar, D Kreger, C McLellan, D L Murphy.   

Abstract

Utilizing a double-blind crossover design, the hormonal effects of high dose, 2 mg/kg, were compared to low dose, 0.4 mg (approx. 5 micrograms/kg), naloxone administration in physically healthy humans. A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect on plasma or serum levels of prolactin, follicle stimulating hormone, luteinizing hormone, norepinephrine or epinephrine. These results confirm involvement of the endogenous opioid system (EOS) in the tonic regulation of the hypothalamicpituitary-adrenal axis, but fail to find evidence of EOS involvement in the regulation of adrenal medullary function or the gonadotrophic axis in man. The results are however consistent with a continuing action of naloxone as an EOS antagonist even at high doses in man.

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Year:  1985        PMID： 3930990     DOI： 10.1016/0143-4179(85)90010-1

Source DB:  PubMed          Journal:  Neuropeptides        ISSN： 0143-4179            Impact factor:   3.286


  5 in total

1.  Naltrexone effects on cortisol secretion in women and men in relation to a family history of alcoholism: studies from the Oklahoma Family Health Patterns Project.

Authors:  William R Lovallo; Andrea C King; Noha H Farag; Kristen H Sorocco; Andrew J Cohoon; Andrea S Vincent
Journal:  Psychoneuroendocrinology       Date:  2012-05-08       Impact factor: 4.905

2.  Does naloxone reinstate secondary hyperalgesia in humans after resolution of a burn injury? A placebo-controlled, double-blind, randomized, cross-over study.

Authors:  Manuel P Pereira; Mads U Werner; Thomas K Ringsted; Michael C Rowbotham; Bradley K Taylor; Joergen B Dahl
Journal:  PLoS One       Date:  2013-05-31       Impact factor: 3.240

3.  Effects of target-controlled infusion of high-dose naloxone on pain and hyperalgesia in a human thermal injury model: a study protocol: A randomized, double-blind, placebo-controlled, crossover trial with an enriched design.

Authors:  Anders D Springborg; Elisabeth K Jensen; Bradley K Taylor; Mads U Werner
Journal:  Medicine (Baltimore)       Date:  2016-11       Impact factor: 1.889

4.  Effect of a high-dose target-controlled naloxone infusion on pain and hyperalgesia in patients following groin hernia repair: study protocol for a randomized controlled trial.

Authors:  M P Pereira; M U Werner; J B Dahl; Manuel Pedro Pereira; Mads Utke Werner; Joergen Berg Dahl
Journal:  Trials       Date:  2015-11-10       Impact factor: 2.279

5.  High-dose naloxone: Effects by late administration on pain and hyperalgesia following a human heat injury model. A randomized, double-blind, placebo-controlled, crossover trial with an enriched enrollment design.

Authors:  Anders Deichmann Springborg; Elisabeth Kjær Jensen; Mads Kreilgaard; Morten Aagaard Petersen; Theodoros Papathanasiou; Trine Meldgaard Lund; Bradley Kenneth Taylor; Mads Utke Werner
Journal:  PLoS One       Date:  2020-11-12       Impact factor: 3.752
  5 in total

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