Literature DB >> 3930124

Serum protein binding of tolbutamide in patients treated with antiepileptic drugs.

M C Fernández, S Erill, M I Lucena, E Pita, N Pérez-Alférez.   

Abstract

The possible development of a displacement interaction involving tolbutamide, in epileptic patients, has been explored by studying the serum protein binding of this drug in vitro in 199 samples of sera from patients treated with antiepileptic agents included in a programme of therapeutic drug monitoring. 82 of the samples were from patients receiving a single drug, 86 from patients treated with 2 drugs, and 31 from patients treated with 3 drugs. The free fraction of tolbutamide was higher in serum from patients treated with antiepileptic drugs than in serum from untreated 'normal' volunteers. The increase was more marked the greater the number of antiepileptic drugs administered. Valproate appeared to be the most powerful displacing agent.

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Year:  1985        PMID： 3930124     DOI： 10.2165/00003088-198510050-00007

Source DB:  PubMed          Journal:  Clin Pharmacokinet        ISSN： 0312-5963            Impact factor:   6.447


  13 in total

1.  Effects of plasma protein binding of drugs on duration and intensity of pharmacological activity.

Authors:  G Levy
Journal:  J Pharm Sci       Date:  1976-08       Impact factor: 3.534

2.  Age differences in drug binding by plasma proteins: studies on human foetuses, neonates and adults.

Authors:  M Ehrnebo; S Agurell; B Jalling; L O Boréus
Journal:  Eur J Clin Pharmacol       Date:  1971-09       Impact factor: 2.953

Review 3.  Protein binding displacement interactions and their clinical importance.

Authors:  J C McElnay; P F D'Arcy
Journal:  Drugs       Date:  1983-05       Impact factor: 9.546

4.  Binding of drugs to human serum albumin. XIV. The theoretical basis for the interaction between phenytoin and valproate.

Authors:  A Kober; Y Olsson; I Sjöholm
Journal:  Mol Pharmacol       Date:  1980-09       Impact factor: 4.436

5.  Serum protein binding of diazepam and its displacement by valproic acid in vitro.

Authors:  S Dhillon; A Richens
Journal:  Br J Clin Pharmacol       Date:  1981-10       Impact factor: 4.335

Review 6.  Clinical pharmacokinetics of sulphonylurea hypoglycaemic drugs.

Authors:  L Balant
Journal:  Clin Pharmacokinet       Date:  1981 May-Jun       Impact factor: 6.447

7.  Plasma protein displacement interactions are rarely of clinical significance.

Authors:  E M Sellers
Journal:  Pharmacology       Date:  1979       Impact factor: 2.547

Review 8.  Clonazepam. A review of a new anticonvulsant drug.

Authors:  T R Browne
Journal:  Arch Neurol       Date:  1976-05

9.  Influence of acute viral hepatitis on disposition and plasma binding of tolbutamide.

Authors:  R L Williams; T F Blaschke; P J Meffin; K L Melmon; M Rowland
Journal:  Clin Pharmacol Ther       Date:  1977-03       Impact factor: 6.875

Review 10.  Drug interactions with valproic acid.

Authors:  R H Levy; K M Koch
Journal:  Drugs       Date:  1982-12       Impact factor: 9.546
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  4 in total

Review 1.  Pharmacokinetic drug interactions with phenytoin (Part II).

Authors:  R L Nation; A M Evans; R W Milne
Journal:  Clin Pharmacokinet       Date:  1990-02       Impact factor: 6.447

Review 2.  Erythrocytes and the transport of drugs and endogenous compounds.

Authors:  M S Highley; E A De Bruijn
Journal:  Pharm Res       Date:  1996-02       Impact factor: 4.200

3.  Pharmacokinetics of chlorpropamide in epileptic patients: effects of enzyme induction and urine pH on chlorpropamide elimination.

Authors:  P J Neuvonen; S Kärkkäinen; R Lehtovaara
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

Review 4.  Pharmacokinetic-pharmacodynamic relationships of oral hypoglycaemic agents. An update.

Authors:  P Marchetti; R Navalesi
Journal:  Clin Pharmacokinet       Date:  1989-02       Impact factor: 6.447
  4 in total

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