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Literature DB >> 3929768

The stoichiometry of the exchange catalysed by the mitochondrial calcium/sodium antiporter.

Abstract

Rat heart mitochondria respiring on succinate in the presence of Ruthenium Red (to inhibit uptake on the Ca2+ uniporter) released Ca2+ on the calcium/sodium antiporter until a steady state was reached. Addition of the ionophore A23187 (which catalyses Ca2+/2H+ exchange) did not perturb this steady state. Thermodynamic analysis showed that if a Ca2+/nNa+ exchange with any value of n other than 2 was at equilibrium, addition of A23187 would cause an obvious change in extramitochondrial free [Ca2+]. Therefore the endogenous calcium/sodium antiporter of mitochondria catalyses electroneutral Ca2+/2Na+ exchange.

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Year: 1985 PMID： 3929768 PMCID： PMC1145162 DOI： 10.1042/bj2290161

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

26 in total

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Authors: M Crompton; M Künzi; E Carafoli
Journal: Eur J Biochem Date: 1977-10-03

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Authors: M Crompton; I Heid
Journal: Eur J Biochem Date: 1978-11-15

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Authors: M Crompton; R Moser; H Lüdi; E Carafoli
Journal: Eur J Biochem Date: 1978-01-02

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Authors: D G Nicholls
Journal: Biochem J Date: 1978-03-15 Impact factor: 3.857

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Authors: J H Luft
Journal: Anat Rec Date: 1971-11

6. A23187: a divalent cation ionophore.

Authors: P W Reed; H A Lardy
Journal: J Biol Chem Date: 1972-11-10 Impact factor: 5.157

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Authors: D G Nicholls; M Crompton
Journal: FEBS Lett Date: 1980-03-10 Impact factor: 4.124

8. The resolution of calcium fluxes in heart and liver mitochondria using the lanthanide series.

Authors: M Crompton; I Heid; C Baschera; E Carafoli
Journal: FEBS Lett Date: 1979-08-15 Impact factor: 4.124

9. The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria.

Authors: D G Nicholls
Journal: Biochem J Date: 1978-11-15 Impact factor: 3.857

10. Some effects of ionophore A23187 on energy utilization and the distribution of cations and anions in mitochondria.

Authors: D R Pfeiffer; S M Hutson; R F Kauffman; H A Lardy
Journal: Biochemistry Date: 1976-06-15 Impact factor: 3.162

20 in total

Review 1. Interplay between mitochondria and cellular calcium signalling.

Authors: Jake Jacobson; Michael R Duchen
Journal: Mol Cell Biochem Date: 2004 Jan-Feb Impact factor: 3.396

2. A biophysically based mathematical model for the kinetics of mitochondrial Na+-Ca2+ antiporter.

Authors: Ranjan K Pradhan; Daniel A Beard; Ranjan K Dash
Journal: Biophys J Date: 2010-01-20 Impact factor: 4.033

Review 3. Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms.

Authors: Thomas E Gunter; Shey-Shing Sheu
Journal: Biochim Biophys Acta Date: 2009-01-06

Review 4. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.

Authors: Dmitry B Zorov; Magdalena Juhaszova; Steven J Sollott
Journal: Physiol Rev Date: 2014-07 Impact factor: 37.312

Review 5. Molecular identity and functional properties of the mitochondrial Na+/Ca2+ exchanger.

Authors: Raz Palty; Michal Hershfinkel; Israel Sekler
Journal: J Biol Chem Date: 2012-07-20 Impact factor: 5.157

Review 6. Mitochondria as sensors and regulators of calcium signalling.

Authors: Rosario Rizzuto; Diego De Stefani; Anna Raffaello; Cristina Mammucari
Journal: Nat Rev Mol Cell Biol Date: 2012-08-01 Impact factor: 94.444

7. The effects of Mg2+ and adenine nucleotides on the sensitivity of the heart mitochondrial Na+-Ca2+ carrier to extramitochondrial Ca2+. A study using arsenazo III-loaded mitochondria.

Authors: L H Hayat; M Crompton
Journal: Biochem J Date: 1987-06-15 Impact factor: 3.857