Literature DB >> 3929159

Multiple sclerosis: free light chains in cerebrospinal fluid.

R A Rudick, D R Peter, J M Bidlack, D W Knutson.   

Abstract

We found free light chains in the CSF of 18 MS patients, but not in any of 14 patients with other neurologic disease. CSF from all MS patients contained kappa and lambda chain dimers, less frequently contained light chain monomers, and never contained free gamma heavy chains. Light chains were not detected in matched serum samples. CSF from MS patients did not release free light chains from whole IgG in CSF of controls. The findings suggest that these free light chains originate in plasma cells, not from degradation of whole IgG.

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Year:  1985        PMID： 3929159     DOI： 10.1212/wnl.35.10.1443

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  12 in total

1.  Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis.

Authors:  Stefan Presslauer; Dejan Milosavljevic; Thomas Brücke; Peter Bayer; Wolfgang Hübl; Walter Hübl
Journal:  J Neurol       Date:  2008-07-17       Impact factor: 4.849

2.  Urine free light chains in SLE: clonal markers of B-cell activity and potential link to in vivo secreted Ig.

Authors:  J E Hopper; J Golbus; C Meyer; G A Ferrer
Journal:  J Clin Immunol       Date:  2000-03       Impact factor: 8.317

3.  Free light chains in the CSF in multiple sclerosis.

Authors:  F Bracco; P Gallo; R Menna; L Battistin; B Tavolato
Journal:  J Neurol       Date:  1987-06       Impact factor: 4.849

4.  Oligoclonal banding of IgG in CSF, blood-brain barrier function, and MRI findings in patients with sarcoidosis, systemic lupus erythematosus, and Behçet's disease involving the nervous system.

Authors:  B N McLean; D Miller; E J Thompson
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-05       Impact factor: 10.154

5.  Immunoglobulin M in the cerebrospinal fluid: an indicator of recent immunological stimulation.

Authors:  M K Sharief; E J Thompson
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-08       Impact factor: 10.154

6.  Cyclosporin A curtails the progression of free light chain synthesis in the CSF of patients with multiple sclerosis.

Authors:  B N McLean; P Rudge; E J Thompson
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-04       Impact factor: 10.154

7.  Maternally derived immunoglobulin light chain is present in the fetal mammalian CNS.

Authors:  J A Weiner; J Chun
Journal:  J Neurosci       Date:  1997-05-01       Impact factor: 6.167

8.  Experimental allergic encephalomyelitis in the monkey: humoral immunity and blood-brain barrier function.

Authors:  P Gallo; D Cupic; F Bracco; L Krzalic; B Tavolato; L Battistin
Journal:  Ital J Neurol Sci       Date:  1989-12

9.  Assessment of Intrathecal Free Light Chain Synthesis: Comparison of Different Quantitative Methods with the Detection of Oligoclonal Free Light Chains by Isoelectric Focusing and Affinity-Mediated Immunoblotting.

Authors:  David Zeman; Pavlína Kušnierová; Zdeněk Švagera; František Všianský; Monika Byrtusová; Pavel Hradílek; Barbora Kurková; Olga Zapletalová; Vladimír Bartoš
Journal:  PLoS One       Date:  2016-11-15       Impact factor: 3.240

10.  Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study.

Authors:  C E Leurs; Ham Twaalfhoven; B I Lissenberg-Witte; V van Pesch; I Dujmovic; J Drulovic; M Castellazzi; T Bellini; M Pugliatti; J Kuhle; L M Villar; J C Alvarez-Cermeño; R Alvarez-Lafuente; H Hegen; F Deisenhammer; L M Walchhofer; E Thouvenot; M Comabella; X Montalban; L Vécsei; C Rajda; D Galimberti; E Scarpini; A Altintas; K Rejdak; J L Frederiksen; G Pihl-Jensen; Peh Jensen; M Khalil; M M Voortman; F Fazekas; A Saiz; D La Puma; M Vercammen; L Vanopdenbosch; Bmj Uitdehaag; J Killestein; C Bridel; C Teunissen
Journal:  Mult Scler       Date:  2019-05-08       Impact factor: 6.312
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