Non-neural malignancy complicating neurofibromatosis in two relatives.

In a family with neurofibromatosis, an affected 16-year-old male developed undifferentiated lymphoma that evolved into acute lymphocytic leukemia. Five years later, his 7-month-old nephew with neurofibromatosis developed a prostatic embryonal rhabdomyosarcoma. This illustrates familial neurofibromatosis complicated by non-neural malignancy in relatives.