Literature DB >> 3926951

Biochemical differences among scrapie-associated fibrils support the biological diversity of scrapie agents.

R J Kascsak, R Rubenstein, P A Merz, R I Carp, H M Wisniewski, H Diringer.   

Abstract

Scrapie-associated fibrils (SAF) were isolated and purified from animals infected with three different scrapie agents: ME7 and 139A in mice, and 263K in hamsters. Mouse ME7 and 139A SAF differed from hamster 263K SAF in morphology, sedimentation rate and protein composition. SAF from the three scrapie agents were distinguishable from each other by their sensitivity to proteinase K digestion. SAF copurified with infectivity in both the hamster and mouse systems. SAF appear to be a unique class of structures which are related but specific for each individual scrapie agent. These properties may correlate with the biological and pathological differences seen among these agents.

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Year:  1985        PMID： 3926951     DOI： 10.1099/0022-1317-66-8-1715

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  39 in total

Review 1.  The prion strain phenomenon: molecular basis and unprecedented features.

Authors:  Rodrigo Morales; Karim Abid; Claudio Soto
Journal:  Biochim Biophys Acta       Date:  2006-12-15

2.  Characterization of major peptides in Creutzfeldt-Jakob disease and scrapie.

Authors:  T Sklaviadis; L Manuelidis; E E Manuelidis
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

3.  Scrapie: Report of an outbreak and brief review.

Authors:  L Petrie; B Heath; D Harold
Journal:  Can Vet J       Date:  1989-04       Impact factor: 1.008

4.  Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes.

Authors:  J F Diedrich; H Minnigan; R I Carp; J N Whitaker; R Race; W Frey; A T Haase
Journal:  J Virol       Date:  1991-09       Impact factor: 5.103

5.  A 54-kDa normal cellular protein may be the precursor of the scrapie agent protease-resistant protein.

Authors:  P E Bendheim; D C Bolton
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

6.  Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains.

Authors:  R J Kascsak; R Rubenstein; P A Merz; R I Carp; N K Robakis; H M Wisniewski; H Diringer
Journal:  J Virol       Date:  1986-09       Impact factor: 5.103

7.  Immunological analysis of host and agent effects on Creutzfeldt-Jakob disease and scrapie prion proteins.

Authors:  J M Bockman; D T Kingsbury
Journal:  J Virol       Date:  1988-09       Impact factor: 5.103

8.  Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins.

Authors:  R J Kascsak; R Rubenstein; P A Merz; M Tonna-DeMasi; R Fersko; R I Carp; H M Wisniewski; H Diringer
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

9.  A new method for the characterization of strain-specific conformational stability of protease-sensitive and protease-resistant PrPSc.

Authors:  Laura Pirisinu; Michele Di Bari; Stefano Marcon; Gabriele Vaccari; Claudia D'Agostino; Paola Fazzi; Elena Esposito; Roberta Galeno; Jan Langeveld; Umberto Agrimi; Romolo Nonno
Journal:  PLoS One       Date:  2010-09-14       Impact factor: 3.240

10.  Transmission in NFS/N mice of the heritable spongiform encephalopathy associated with the gray tremor mutation.

Authors:  P M Hoffman; R G Rohwer; C MacAuley; J A Bilello; J W Hartley; H C Morse
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205
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