Literature DB >> 3926656

Syntheses of carbon-11 labelled ornithine and lysine. Preliminary accumulation studies in rats with Walker 256 carcinosarcoma.

J M Bolster, W Vaalburg, T H van Dijk, J B Zijlstra, A M Paans, H Wynberg, M G Woldring.   

Abstract

DL-[1-11C]ornithine and lysine have been synthesized by carboxylation of the corresponding alpha-lithioisocyanide with a radiochemical yield of up to 14% without correction for decay. The total preparation time is 50 min. Accumulation of both DL-[1-11C]ornithine and lysine in Walker 256 carcinosarcoma is observed, with a tumor/non-tumor ratio of 4.9 and 4.5 respectively, at 45 min after intravenous injection.

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Year:  1985        PMID： 3926656     DOI： 10.1016/0020-708x(85)90082-1

Source DB:  PubMed          Journal:  Int J Appl Radiat Isot        ISSN： 0020-708X


  3 in total

Review 1.  From Carbon-11-Labeled Amino Acids to Peptides in Positron Emission Tomography: the Synthesis and Clinical Application.

Authors:  Aleksandra Pekošak; Ulrike Filp; Alex J Poot; Albert D Windhorst
Journal:  Mol Imaging Biol       Date:  2018-08       Impact factor: 3.488

2.  Potential radiopharmaceuticals for the detection of ocular melanoma. Part III. A study with 14C and 11C labelled tyrosine and dihydroxyphenylalanine.

Authors:  A van Langevelde; H D van der Molen; J G Journée-de Korver; A M Paans; E K Pauwels; W Vaalburg
Journal:  Eur J Nucl Med       Date:  1988

3.  Carbon-11 labelled tyrosine to study tumor metabolism by positron emission tomography (PET).

Authors:  J M Bolster; W Vaalburg; A M Paans; T H van Dijk; P H Elsinga; J B Zijlstra; D A Piers; N H Mulder; M G Woldring; H Wynberg
Journal:  Eur J Nucl Med       Date:  1986
  3 in total

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