Literature DB >> 3926531

Effect of coenzyme-A, NAD, alpha lipoic-acid and cocarboxylase on survival of rats with galactosamine-induced severe hepatitis.

H Thölen, W Zimmerli, Z Rajacic.   

Abstract

Galactosamine, a selective hepatotoxin, produces in rats histologic alterations, which show the characteristics of severe human viral hepatitis. In the present study the efficacy of two different cofactor regimens (coenzyme A, NAD, alpha lipoic-acid, cocarboxylase) in rats with fulminant galactosamine hepatitis were tested. The results showed an improvement of the short-term survival with a short-term treatment and definitely better survival with a long-term regimen with cofactors.

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Year:  1985        PMID： 3926531     DOI： 10.1007/bf01952133

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Protection of rat kidneys against HgCl2-induced acute renal failure by induction of high urine flow without renin suppression.

Authors:  G Thiel; F Brunner; P Wunderlich; M Huguenin; B Bienko; J Torhorst; L Peters-Haefeli; E J Kirchertz; G Peters
Journal:  Kidney Int Suppl       Date:  1976-10       Impact factor: 10.545

2.  Permeation of nucleotidic coenzymes into liver cells.

Authors:  H Thölen; R Mordhorst
Journal:  Int J Clin Pharmacol       Date:  1974-09

3.  Action of methanethiol on Na+, K+-ATPase: implications for hepatic coma.

Authors:  D Foster; K Ahmed; L Zieve
Journal:  Ann N Y Acad Sci       Date:  1974       Impact factor: 5.691

4.  Experimental hepatitis induced by D-galactosamine.

Authors:  D Keppler; R Lesch; W Reutter; K Decker
Journal:  Exp Mol Pathol       Date:  1968-10       Impact factor: 3.362

5.  A technique for repeated renal clearance measurements in undisturbed rats.

Authors:  A Engberg
Journal:  Acta Physiol Scand       Date:  1969 Jan-Feb

6.  Mannitol treatment of cerebral edema in rats with galactosamine-induced severe hepatitis.

Authors:  W Zimmerli; C Grubinger; H Thölen; M Oberholzer; L Bianchi
Journal:  Experientia       Date:  1981-12-15

7.  Hepatic and cerebral coenzyme A contents after intravenous injection of coenzyme A in rats.

Authors:  H Thölen; R Mordhorst
Journal:  Experientia       Date:  1976

8.  Cerebral edema in the rat with galactosamine induced severe hepatitis.

Authors:  U B Gröflin; H Thölen
Journal:  Experientia       Date:  1978-11-15

9.  Controlled trial of dexamethasone and mannitol for the cerebral oedema of fulminant hepatic failure.

Authors:  J Canalese; A E Gimson; C Davis; P J Mellon; M Davis; R Williams
Journal:  Gut       Date:  1982-07       Impact factor: 23.059

10.  A model of fulminant hepatic failure in the rabbit.

Authors:  B L Blitzer; J G Waggoner; E A Jones; H R Gralnick; D Towne; J Butler; V Weise; I J Kopin; I Walters; P F Teychenne; D G Goodman; P D Berk
Journal:  Gastroenterology       Date:  1978-04       Impact factor: 22.682
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