Literature DB >> 3926383

Inflammation-induced stimulation of the synthesis of prostaglandins and lipoxygenase-reaction products in rabbit cornea.

H E Bazan, D L Birkle, R W Beuerman, N G Bazan.   

Abstract

The cyclooxygenase and lipoxygenase pathways that produce prostaglandins (PGs) and hydroxyeicosatetraenoic acids (HETEs) were studied in inflamed rabbit cornea. A cryogenic lesion was induced and five days later the epithelium, stroma and endothelium were isolated and incubated with [1-14C]arachidonic acid. After lesioning, the arachidonic acid metabolites, thromboxane B2, PGF2 alpha and 6-keto-PGF1 alpha exhibited the greatest increase in the stroma. Lipoxygenase products were formed in the three layers also, although 12-HETE predominated. The correlation between the synthesis of these compounds and corneal injury is discussed.

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Year:  1985        PMID： 3926383     DOI： 10.3109/02713688509000847

Source DB:  PubMed          Journal:  Curr Eye Res        ISSN： 0271-3683            Impact factor:   2.424


  8 in total

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  8 in total

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