Literature DB >> 3926296

Localization of a cytochrome P-450 isozyme (cytochrome P-450 PB-B) and NADPH-cytochrome P-450 reductase in rat nasal mucosa.

J M Voigt, F P Guengerich, J Baron.   

Abstract

Antibodies raised against cytochrome P-450 PB-B, the major phenobarbital-inducible isozyme of rat hepatic microsomal cytochrome P-450, and NADPH-cytochrome P-450 reductase (EC 1.6.2.4) were employed to determine the cellular localizations of these enzymes within the nasal mucosa of untreated rats. Immunohistochemical staining for each enzyme was detected at the light microscopic level within the respiratory and olfactory epithelia, duct and acinar cells of seromucous glands in the respiratory region, and duct and acinar cells of Bowman's glands in the olfactory region. These findings demonstrate that a number of different cell types in rat nasal mucosa contain enzymes which participate in the monooxygenations of chemical carcinogens and other xenobiotics.

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Year:  1985        PMID： 3926296     DOI： 10.1016/0304-3835(85)90180-6

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  11 in total

1.  The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450.

Authors:  G I Murray; T S Barnes; H F Sewell; S W Ewen; W T Melvin; M D Burke
Journal:  Br J Clin Pharmacol       Date:  1988-04       Impact factor: 4.335

2.  Cyclophosphamide has Long-Term Effects on Proliferation in Olfactory Epithelia.

Authors:  Nora Awadallah; Kara Proctor; Kyle B Joseph; Eugene R Delay; Rona J Delay
Journal:  Chem Senses       Date:  2020-03-25       Impact factor: 3.160

3.  Immunohistochemical localisation of six glutathione S-transferases within the nasal cavity of the rat.

Authors:  K K Banger; J R Foster; E A Lock; C J Reed
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

4.  Differential expression of alpha, mu, and pi classes of glutathione S-transferases in chemosensory mucosae of rats during development.

Authors:  N S Krishna; T V Getchell; M L Getchell
Journal:  Cell Tissue Res       Date:  1994-03       Impact factor: 5.249

5.  Localization and differential induction of cytochrome P450IVA and acyl-CoA oxidase in rat liver.

Authors:  D R Bell; R G Bars; G G Gibson; C R Elcombe
Journal:  Biochem J       Date:  1991-04-01       Impact factor: 3.857

6.  Epithelial binding of 1,1,2,2-tetrachloroethane in the respiratory and upper alimentary tract.

Authors:  C Eriksson; E B Brittebo
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

7.  Acute lesions in rats caused by 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) or nitromin: a comparison with rates of reduction in microsomal systems from target organs.

Authors:  I N White; A Cahill; A Davies; P Carthew
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

8.  Biotransformation enzyme activities in the olfactory organ of rainbow trout (Oncorhynchus mykiss). Immunocytochemical localization of cytochrome P4501A1 and its induction by β-naphthoflavone.

Authors:  G Monod; D Saucier; E Perdu-Durand; M Diallo; J P Cravedi; L Astic
Journal:  Fish Physiol Biochem       Date:  1994-12       Impact factor: 2.794

9.  Activation and toxicity of bromobenzene in nasal tissue in mice.

Authors:  E B Brittebo; C Eriksson; I Brandt
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

10.  Glutathione S-transferases in rat olfactory epithelium: purification, molecular properties and odorant biotransformation.

Authors:  N Ben-Arie; M Khen; D Lancet
Journal:  Biochem J       Date:  1993-06-01       Impact factor: 3.857
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