Literature DB >> 3925960

Inhibition of 3H-glibenclamide binding to sulfonylurea receptors by oral antidiabetics.

K Geisen, V Hitzel, R Okomonopoulos, J Pünter, R Weyer, H D Summ.   

Abstract

Specific binding of 3H-glibenclamide (HB 419) is observed with membranes from rat cerebral cortex and rat beta-cell tumor. 3H-Glibenclamide binding is of high affinity, reversible, saturable, and can be displaced by oral antidiabetics of different structural types. Half maximal inhibition of binding correlates with the hypoglycemic action of the compounds.

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Year:  1985        PMID： 3925960

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  14 in total

1.  K+ channel openers activate brain sulfonylurea-sensitive K+ channels and block neurosecretion.

Authors:  H Schmid-Antomarchi; S Amoroso; M Fosset; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

Review 2.  Pharmacology and regulation of ATP-sensitive K+ channels.

Authors:  J R de Weille; M Fosset; C Mourre; H Schmid-Antomarchi; H Bernardi; M Lazdunski
Journal:  Pflugers Arch       Date:  1989       Impact factor: 3.657

3.  Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells.

Authors:  S E Ozanne; P C Guest; J C Hutton; C N Hales
Journal:  Diabetologia       Date:  1995-03       Impact factor: 10.122

4.  Location of the sulphonylurea receptor at the cytoplasmic face of the beta-cell membrane.

Authors:  M Schwanstecher; C Schwanstecher; C Dickel; F Chudziak; A Moshiri; U Panten
Journal:  Br J Pharmacol       Date:  1994-11       Impact factor: 8.739

5.  Endosulfine, an endogenous peptidic ligand for the sulfonylurea receptor: purification and partial characterization from ovine brain.

Authors:  A Virsolvy-Vergine; H Leray; S Kuroki; B Lupo; M Dufour; D Bataille
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

6.  Effect of MgATP on pinacidil-induced displacement of glibenclamide from the sulphonylurea receptor in a pancreatic beta-cell line and rat cerebral cortex.

Authors:  M Schwanstecher; C Brandt; S Behrends; U Schaupp; U Panten
Journal:  Br J Pharmacol       Date:  1992-06       Impact factor: 8.739

7.  Characterization of the solubilized glibenclamide receptor in a hamster pancreatic beta-cell line, HIT T15.

Authors:  I Niki; M Welsh; P O Berggren; P Hubbard; S J Ashcroft
Journal:  Biochem J       Date:  1991-08-01       Impact factor: 3.857

8.  Phosphate and thiophosphate group donating adenine and guanine nucleotides inhibit glibenclamide binding to membranes from pancreatic islets.

Authors:  M Schwanstecher; S Löser; I Rietze; U Panten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-01       Impact factor: 3.000

9.  Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line.

Authors:  N C Sturgess; R Z Kozlowski; C A Carrington; C N Hales; M L Ashford
Journal:  Br J Pharmacol       Date:  1988-09       Impact factor: 8.739

10.  Characterization, purification, and affinity labeling of the brain [3H]glibenclamide-binding protein, a putative neuronal ATP-regulated K+ channel.

Authors:  H Bernardi; M Fosset; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205
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