Literature DB >> 3925878

In vivo distribution and activity of aphidicolin on dividing and quiescent cells.

S Spadari, F Focher, C Kuenzle, E J Corey, A G Myers, N Hardt, A Rebuzzini, G Ciarrocchi, G Pedrali-Noy.   

Abstract

In view of a possible use of aphidicolin, an inhibitor of DNA polymerases (including viral DNA polymerases), to control excessive cell proliferation we have investigated: the effect of the drug on the growth of several human neoplastic cells; the activity of synthetic analogs aimed at relating the structural feature of aphidicolin to cytotoxicity; the in vivo fate and distribution of aphidicolin in different fluids, organs and tissues of mice following parenteral and/or peroral administration.

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Year:  1985        PMID： 3925878     DOI： 10.1016/0166-3542(85)90035-x

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  7 in total

1.  Calcium release from intra-axonal endoplasmic reticulum leads to axon degeneration through mitochondrial dysfunction.

Authors:  Rosario Villegas; Nicolas W Martinez; Jorge Lillo; Phillipe Pihan; Diego Hernandez; Jeffery L Twiss; Felipe A Court
Journal:  J Neurosci       Date:  2014-05-21       Impact factor: 6.167

2.  Structure-activity relationships for the inhibition of DNA polymerase alpha by aphidicolin derivatives.

Authors:  G Prasad; R A Edelson; P D Gorycki; T L Macdonald
Journal:  Nucleic Acids Res       Date:  1989-08-11       Impact factor: 16.971

3.  Axonal Degeneration Is Mediated by Necroptosis Activation.

Authors:  Macarena S Arrázola; Cristian Saquel; Romina J Catalán; Sebastián A Barrientos; Diego E Hernandez; Nicolás W Martínez; Alejandra Catenaccio; Felipe A Court
Journal:  J Neurosci       Date:  2019-03-08       Impact factor: 6.167

4.  The ternary complex factor Net regulates cell migration through inhibition of PAI-1 expression.

Authors:  Gilles Buchwalter; Christian Gross; Bohdan Wasylyk
Journal:  Mol Cell Biol       Date:  2005-12       Impact factor: 4.272

5.  Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice.

Authors:  Rachel A Kline; Kosala N Dissanayake; Maica Llavero Hurtado; Nicolás W Martínez; Alexander Ahl; Alannah J Mole; Douglas J Lamont; Felipe A Court; Richard R Ribchester; Thomas M Wishart; Lyndsay M Murray
Journal:  Neurobiol Dis       Date:  2019-06-06       Impact factor: 5.996

6.  Neuronal activity-dependent ATP enhances the pro-growth effect of repair Schwann cell extracellular vesicles by increasing their miRNA-21 loading.

Authors:  Cristian Saquel; Romina J Catalan; Rodrigo Lopez-Leal; Ramon A Ramirez; David Necuñir; Ursula Wyneken; Christophe Lamaze; Felipe A Court
Journal:  Front Cell Neurosci       Date:  2022-09-23       Impact factor: 6.147

7.  High content image based analysis identifies cell cycle inhibitors as regulators of Ebola virus infection.

Authors:  Krishna P Kota; Jacqueline G Benko; Rajini Mudhasani; Cary Retterer; Julie P Tran; Sina Bavari; Rekha G Panchal
Journal:  Viruses       Date:  2012-09-25       Impact factor: 5.048
  7 in total

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