| Literature DB >> 3925391 |
J Greenwood, P J Luthert, O E Pratt, P L Lantos.
Abstract
Integrity of the blood-brain barrier to the small polar tracer mannitol was maintained for up to 30 min during an in situ perfusion of the brain with a saline-based solution containing the metabolic inhibitor 2,4-dinitrophenol. The patency of the capillary bed after perfusion was demonstrated by injecting a solution of Indian ink and gelatin, and ultrastructural examination showed the microvasculature to be well preserved. These findings suggest that the blood-brain barrier can be studied under conditions that are independent of normal cerebral function and metabolism.Entities:
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Year: 1985 PMID： 3925391 DOI： 10.1016/0304-3940(85)90133-8
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046