Literature DB >> 3924659

NADPH-dependent generation of H2O2 in a thyroid particulate fraction requires Ca2+.

D Deme, A Virion, N A Hammou, J Pommier.   

Abstract

The action of Ca2+ on H2O2 formation catalyzed by an NADPH-dependent H2O2-generating system was studied in a thyroid particulate fraction. It was shown that H2O2 formation was inhibited by EGTA and restored in the presence of micromolar concentrations of free Ca2+, and that Mg2+ was unable to restore the activity of the EGTA-inhibited particulate fraction. Consequently, NADPH-dependent H2O2 formation requires Ca2+, and the Ca2+ stimulation of this process is specific and reversible.

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Year:  1985        PMID： 3924659     DOI： 10.1016/0014-5793(85)81349-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

Review 1.  Role of the NADPH Oxidases DUOX and NOX4 in Thyroid Oxidative Stress.

Authors:  Denise P Carvalho; Corinne Dupuy
Journal:  Eur Thyroid J       Date:  2013-08-30

2.  Regulation of the thyroid NADPH-dependent H2O2 generator by Ca2+: studies with phenylarsine oxide in thyroid plasma membrane.

Authors:  Y Gorin; A M Leseney; R Ohayon; C Dupuy; J Pommier; A Virion; D Dème
Journal:  Biochem J       Date:  1997-01-15       Impact factor: 3.857

3.  The Ca2+/NADPH-dependent H2O2 generator in thyroid plasma membrane: inhibition by diphenyleneiodonium.

Authors:  D Dème; J Doussiere; V De Sandro; C Dupuy; J Pommier; A Virion
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

4.  Monoamine oxidase activity and triiodothyronine biosynthesis in human cultured thyroid cells.

Authors:  Z Kraiem; O Sadeh; M B Youdim
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739

Review 5.  Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases.

Authors:  Thomas L Leto; Stanislas Morand; Darrell Hurt; Takehiko Ueyama
Journal:  Antioxid Redox Signal       Date:  2009-10       Impact factor: 8.401

6.  The stimulus-sensitive H2O2-generating system present in human fat-cell plasma membranes is multireceptor-linked and under antagonistic control by hormones and cytokines.

Authors:  H I Krieger-Brauer; H Kather
Journal:  Biochem J       Date:  1995-04-15       Impact factor: 3.857

7.  Activation of the NADPH-dependent H2O2-generating system in pig thyroid particulate fraction by limited proteolysis and Zn2+ treatment.

Authors:  C Dupuy; A Virion; V De Sandro; R Ohayon; J Kaniewski; J Pommier; D Dème
Journal:  Biochem J       Date:  1992-04-15       Impact factor: 3.857

8.  Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase.

Authors:  H I Krieger-Brauer; H Kather
Journal:  J Clin Invest       Date:  1992-03       Impact factor: 14.808

9.  Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.

Authors:  Ji Sun
Journal:  Nat Struct Mol Biol       Date:  2020-09-14       Impact factor: 15.369
  9 in total

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