Literature DB >> 3924451

Abnormal lymphocyte response to exogenous interleukin-2 in homosexuals with acquired immune deficiency syndrome (AIDS) and AIDS related complex (ARC).

J L Murray, E M Hersh, J M Reuben, C G Munn, P W Mansell.   

Abstract

Interleukin-2 (IL-2) production as well as the response of lymphocytes to exogenous IL-2 was measured in asymptomatic homosexuals, patients with acquired immune deficiency syndrome (AIDS), and homosexuals with prodromal symptoms. IL-2 production following lectin stimulation was not significantly different in homosexuals compared to age matched heterosexual controls. In contrast, the response of lymphocytes to exogenous IL-2 was significantly decreased in AIDS and homosexuals with prodromal symptoms compared to asymptomatic homosexuals and heterosexual controls. These data, combined with the data of others, suggest that an underlying immune defect in AIDS is abnormal IL-2 receptor expression and resultant poor IL-2 response.

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Year:  1985        PMID： 3924451      PMCID： PMC1577005     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  15 in total

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Authors:  S Gillis; K A Smith
Journal:  Nature       Date:  1977-07-14       Impact factor: 49.962

2.  The formation of stable E rosettes after neuraminidase treatment of either human peripheral blood lymphocytes or of sheep red blood cells.

Authors:  U Galili; M Schlesinger
Journal:  J Immunol       Date:  1974-05       Impact factor: 5.422

3.  T cell growth factor: parameters of production and a quantitative microassay for activity.

Authors:  S Gillis; M M Ferm; W Ou; K A Smith
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

4.  Immunological characterization of homosexual males.

Authors:  J M Reuben; E M Hersh; P W Mansell; G Newell; A Rios; R Rossen; A L Goldstein; J E McClure
Journal:  Cancer Res       Date:  1983-02       Impact factor: 12.701

5.  A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor.

Authors:  W J Leonard; J M Depper; T Uchiyama; K A Smith; T A Waldmann; W C Greene
Journal:  Nature       Date:  1982-11-18       Impact factor: 49.962

6.  The regulatory role of adenosine-activated T-lymphocyte subset on the immune response in humans. I. Mitogenic response and production of mediators.

Authors:  H Bessler; M Djaldetti; C Moroz
Journal:  Cell Immunol       Date:  1982-11-01       Impact factor: 4.868

7.  Interleukin-2 correction of defective in vitro T-cell mitogenesis in patients with common varied immunodeficiency.

Authors:  G Kruger; K Welte; N Ciobanu; C Cunningham-Rundles; P Ralph; S Venuta; S Feldman; B Koziner; C Y Wang; M A Moore
Journal:  J Clin Immunol       Date:  1984-07       Impact factor: 8.317

8.  Impaired production of interleukins in patients with cell-mediated immunodeficiencies.

Authors:  R Paganelli; F Aiuti; P C Beverley; R J Levinsky
Journal:  Clin Exp Immunol       Date:  1983-02       Impact factor: 4.330

9.  Interleukin-2 production and response to exogenous interleukin-2 in a patient with the acquired immune deficiency syndrome (AIDS).

Authors:  G J Hauser; T Bino; H Rosenberg; V Zakuth; E Geller; Z Spirer
Journal:  Clin Exp Immunol       Date:  1984-04       Impact factor: 4.330

10.  Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency.

Authors:  M S Gottlieb; R Schroff; H M Schanker; J D Weisman; P T Fan; R A Wolf; A Saxon
Journal:  N Engl J Med       Date:  1981-12-10       Impact factor: 91.245
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  6 in total

1.  Defective T-cell colony formation and IL-2 receptor expression at all stages of HIV infection.

Authors:  A Winkelstein; L A Kingsley; R S Klein; D W Lyter; T L Evans; C R Rinaldo; L D Weaver; L L Machen; R C Schadle
Journal:  Clin Exp Immunol       Date:  1988-03       Impact factor: 4.330

Review 2.  Cellular immunology of HIV-infection.

Authors:  G P Spickett; A G Dalgleish
Journal:  Clin Exp Immunol       Date:  1988-01       Impact factor: 4.330

3.  Humoral-mediated suppression of interleukin 2-dependent target cell proliferation in acquired immune deficiency syndrome (AIDS): interference with normal IL-2 receptor expression.

Authors:  R P Donnelly; M F La Via; K Y Tsang
Journal:  Clin Exp Immunol       Date:  1987-06       Impact factor: 4.330

4.  Effects of interleukin 2 and large envelope glycoprotein (gp 120) of human immunodeficiency virus (HIV) on lymphocyte proliferative responses to cytomegalovirus.

Authors:  J Krowka; D Stites; J Mills; H Hollander; T McHugh; M Busch; L Wilhelm; L Blackwood
Journal:  Clin Exp Immunol       Date:  1988-05       Impact factor: 4.330

5.  Heterogeneous effects of exogenous IL-2 on HIV-specific cell-mediated immunity (CMI).

Authors:  S J Bell; D A Cooper; B E Kemp; R R Doherty; R Penny
Journal:  Clin Exp Immunol       Date:  1992-10       Impact factor: 4.330

6.  Lymphocyte subpopulation profiles and mitogen kinetics in immunological deficiency testing.

Authors:  R M Radvany; M S Schubert; M Kiamar; V Jarzabek; K Koehler-Carone; D Kuban; F Hecht
Journal:  J Clin Immunol       Date:  1987-07       Impact factor: 8.317
  6 in total

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