Literature DB >> 3924200

Drugs prescribed for self poisoners.

L F Prescott, M S Highley.   

Abstract

Of 230 adults admitted for self poisoning over two months, 153 (67%) had previously been taking a total of 309 prescribed drugs. Of these patients, 119 (78%) had been given psychotropic drugs (usually benzodiazepines), 81 (53%) obtained them on repeat prescription, and 47 (31%) had been prescribed multiple psychotropic drugs, often in seemingly illogical combinations. The use of these drugs increased progressively with age and most patients took the same drugs in overdosage as they had been prescribed. Psychotropic drugs were prescribed for more than a third of patients with no psychiatric illness and a normal personality, nearly half of those with existing alcohol or drug abuse problems, and for most of the unemployed. Fewer than a third of the patients suffering from depression were prescribed antidepressants but half had been given benzodiazepines and other potentially depressing drugs. Psychotropic drug use, psychotropic polypharmacy, and the repeat prescribing of these drugs were strongly associated with repeated overdosage and, under certain circumstances, with personality disorder, alcohol or drug abuse, unemployment, and conflict with the law. In the long term psychotropic drugs are unlikely to benefit most self poisoners, and they may do positive harm by inducing apathy and depression and predisposing to self poisoning. The incidence of self poisoning (and repeat overdosage in particular) might be reduced by more care and restraint in the prescribing of these drugs.

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Year:  1985        PMID: 3924200      PMCID: PMC1415810          DOI: 10.1136/bmj.290.6482.1633

Source DB:  PubMed          Journal:  Br Med J (Clin Res Ed)        ISSN: 0267-0623


  19 in total

1.  A follow-up of self-poisoned patients.

Authors:  D R Jones
Journal:  J R Coll Gen Pract       Date:  1977-12

2.  Drug-induced depression and attempted suicide.

Authors:  P M Baker; D B Bartholomeusz; M Siskind; F A Whitlock
Journal:  Med J Aust       Date:  1977-09-03       Impact factor: 7.738

Review 3.  The why and how of hypnotic drugs.

Authors:  I Oswald
Journal:  Br Med J       Date:  1979-05-05

4.  Self poisoning in 1984: a prediction that didn't come true.

Authors:  C Brewer; R Farmer
Journal:  Br Med J (Clin Res Ed)       Date:  1985-02-02

5.  Changing pattern of drugs used for self-poisoning.

Authors:  A T Proudfoot; J Park
Journal:  Br Med J       Date:  1978-01-14

6.  Deliberate self-poisoning: implications for psychotropic drug prescribing in general practice.

Authors:  K Hawton; E Blackstock
Journal:  J R Coll Gen Pract       Date:  1977-09

7.  The respectability of self-poisoning and the fashion of survival.

Authors:  N Kessel
Journal:  J Psychosom Res       Date:  1966-07       Impact factor: 3.006

Review 8.  Psychiatric aspects of acute poisoning with tricyclic and related antidepressants--a ten-year review.

Authors:  I R Starkey; A A Lawson
Journal:  Scott Med J       Date:  1980-10       Impact factor: 0.729

Review 9.  Drug-induced mood disorders.

Authors:  J Ananth; A M Ghadirian
Journal:  Int Pharmacopsychiatry       Date:  1980

10.  Deliberate self-poisoning: a study in London casualty departments.

Authors:  A H Ghodse
Journal:  Br Med J       Date:  1977-03-26
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  8 in total

1.  Reducing paracetamol overdoses.

Authors:  E Fagan; G Wannan
Journal:  BMJ       Date:  1996-12-07

2.  Association between liberalization of Scotland's liquor licensing laws and admissions for self poisoning in West Fife.

Authors:  D B Northridge; J McMurray; A A Lawson
Journal:  Br Med J (Clin Res Ed)       Date:  1986-12-06

Review 3.  Constraints on antidepressant prescribing and principles of cost-effective antidepressant use. Part 1: Depression and its treatment.

Authors:  J A Henry; C A Rivas
Journal:  Pharmacoeconomics       Date:  1997-05       Impact factor: 4.981

Review 4.  Measuring quality of life in patients with depression or anxiety.

Authors:  D Whalley; S P McKenna
Journal:  Pharmacoeconomics       Date:  1995-10       Impact factor: 4.981

Review 5.  The risk-benefit assessment of antidepressant drugs.

Authors:  J A Henry; A J Martin
Journal:  Med Toxicol Adverse Drug Exp       Date:  1987 Nov-Dec

Review 6.  Dextropropoxyphene overdose. Epidemiology, clinical presentation and management.

Authors:  A A Lawson; D B Northridge
Journal:  Med Toxicol Adverse Drug Exp       Date:  1987 Nov-Dec

7.  Deliberate self-poisoning in an Irish county hospital.

Authors:  G T McMahon; K McGarry
Journal:  Ir J Med Sci       Date:  2001 Apr-Jun       Impact factor: 1.568

Review 8.  Epidemiology and relative toxicity of antidepressant drugs in overdose.

Authors:  J A Henry
Journal:  Drug Saf       Date:  1997-06       Impact factor: 5.606

  8 in total

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