| Literature DB >> 3924119 |
H C Stevens, T R Covey, W L Dills.
Abstract
2,5-Anhydro-D-mannitol inhibited glucose synthesis, increased the pyruvate/phosphoenolpyruvate ratio and altered adenine nucleotide concentrations in hepatocytes isolated from fasted rats. The accumulations of 2,5-anhydro-D-mannitol 1,6-diphosphate, an allosteric activator of pyruvate kinase, and of ADP in treated hepatocytes can account for the increase in pyruvate/phosphoenolpyruvate ratio and the inhibition of glucose synthesis from lactate.Entities:
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Year: 1985 PMID： 3924119 DOI： 10.1016/0167-4889(85)90216-2
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002