Literature DB >> 3922822

Valproic acid teratogenicity: demonstration that the biochemical mechanism differs from that of valproate hepatotoxicity.

N A Brown, P B Farmer, M Coakley.   

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Year:  1985        PMID： 3922822     DOI： 10.1042/bst0130075

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


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  7 in total

1.  The disposition of valproate and its metabolites in the late first trimester and early second trimester of pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, co-medication, and the presence of spina bifida.

Authors:  J G Omtzigt; H Nau; F J Los; L Pijpers; D Lindhout
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

2.  Valnoctamide, a non-teratogenic amide derivative of valproic acid, inhibits arachidonic acid activation in vitro by recombinant acyl-CoA synthetase-4.

Authors:  Hiren R Modi; Mireille Basselin; Stanley I Rapoport
Journal:  Bipolar Disord       Date:  2014-07-08       Impact factor: 6.744

3.  Effect of valproate on zinc metabolism in fetal and maternal rats fed normal and zinc-deficient diets.

Authors:  J Vormann; V Höllriegl; H J Merker; T Günther
Journal:  Biol Trace Elem Res       Date:  1986-07       Impact factor: 3.738

4.  Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: a potential drug for bipolar disorder.

Authors:  Hiren R Modi; Mireille Basselin; Ameer Y Taha; Lei O Li; Rosalind A Coleman; Meir Bialer; Stanley I Rapoport
Journal:  Biochim Biophys Acta       Date:  2013-01-23

5.  Sodium valproate inhibits the movement of secretory vesicles in rat hepatocytes.

Authors:  M E Bellringer; K Rahman; R Coleman
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

Review 6.  Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder.

Authors:  Marthe H R Ludtmann; Katrina Boeckeler; Robin S B Williams
Journal:  Semin Cell Dev Biol       Date:  2010-11-18       Impact factor: 7.727

7.  Short-chain carboxylic acids, a new class of teratogens: studies of potential biochemical mechanisms.

Authors:  M E Coakley; S J Rawlings; N A Brown
Journal:  Environ Health Perspect       Date:  1986-12       Impact factor: 9.031
  7 in total

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