| Literature DB >> 3922672 |
Abstract
The metabolism of cytosine arabinoside (araC) in Tetrahymena pyriformis amicronucleate strain W was studied. araC inhibited cell multiplication and protein synthesis at concentrations higher than 0.1 and 0.25 M respectively. araC had no effect on protein synthesis. araC was converted to araCMP, araCDP and araCTP by homogenized cell preparations. A deaminase activity converted araC to uracil arabinoside. The deaminase activity totally inhibited by tetrahydrouridine (THU) at a concn of 4 X 10(-6) M. The Ki for THU was 8 X 10(-8) M.Entities:
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Year: 1985 PMID： 3922672 DOI： 10.1016/0305-0491(85)90468-7
Source DB: PubMed Journal: Comp Biochem Physiol B ISSN： 0305-0491