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Literature DB >> 3922641

Cyclic combination chemotherapy in advanced adenocarcinoma of the lung: comparison of two FAM schedules.

Abstract

Forty patients with advanced adenocarcinoma of the lung were treated by two FAM chemotherapy schedules. Group A (20 patients) received Futraful, adriamycin, and mitomycin C, and group B (20 patients) received 5-fluorouracil, adriamycin, and mitomycin C. The response/stabilization rate was greater for group B (4 partial responses + 4 cases of stable disease) than for group A (no responders + 5 cases of stable disease), and the median survival was longer for group B (32 weeks) than for group A (22 weeks), although the differences did not reach statistical significance in either case (P greater than 0.05). Myelotoxicity was mild in both schedules. Further studies of the two FAM schemes at an escalated dose would be worthwhile.

Entities: Disease Species

Mesh：

Substances：

Year: 1985 PMID： 3922641 DOI： 10.1007/bf00258136

Source DB: PubMed Journal: Cancer Chemother Pharmacol ISSN： 0344-5704 Impact factor: 3.333

11 in total

1. Alkylating agents in bronchogenic carcinoma.

Authors: R A Green; E Humphrey; H Close; M E Patno
Journal: Am J Med Date: 1969-04 Impact factor: 4.965

2. Clinical trials with oral Futraful (INN: Tegafur) in cancer of the head and neck.

Authors: Y Inuyama; M Horiuchi; N Kohno; S Mashino; R Ozu; K Asaoka
Journal: Clin Oncol Date: 1981-06

Review 3. Chemotherapy of metastatic non-small cell bronchogenic carcinoma.

Authors: P C Hoffman; J D Bitran; H M Golomb
Journal: Semin Oncol Date: 1983-03 Impact factor: 4.929

4. Adenocarcinoma of the lung: clinicopathological study.

Authors: P Marabella; H Takita
Journal: J Surg Oncol Date: 1975 Impact factor: 3.454

5. Failure of intensive combination therapy (cyclophosphamide, adriamycin, 5-fluorouracil) to control adenocarcinoma or large-cell anaplastic carcinoma of lung.

Authors: R E Taylor; I E Smith; H T Ford; B M Bryant; A J Casey; J F Smyth
Journal: Cancer Chemother Pharmacol Date: 1980 Impact factor: 3.333

6. The changing histopathology of lung cancer: a review of 1682 cases.

Authors: R G Vincent; J W Pickren; W W Lane; I Bross; H Takita; L Houten; A C Gutierrez; T Rzepka
Journal: Cancer Date: 1977-04 Impact factor: 6.860

7. Mitomycin-C alone and in combination with infused 5-fluorouracil to the treatment of disseminated gastrointestinal carcinomas.

Authors: T R Buroker; P N Kim; L H Baker; V Ratanatharathron; B Wojtaszak; V K Vaitkevicius
Journal: Med Pediatr Oncol Date: 1978

Cyclic combination chemotherapy in advanced adenocarcinoma of the lung: comparison of two FAM schedules.

1. Alkylating agents in bronchogenic carcinoma.

2. Clinical trials with oral Futraful (INN: Tegafur) in cancer of the head and neck.

Review 3. Chemotherapy of metastatic non-small cell bronchogenic carcinoma.

4. Adenocarcinoma of the lung: clinicopathological study.

5. Failure of intensive combination therapy (cyclophosphamide, adriamycin, 5-fluorouracil) to control adenocarcinoma or large-cell anaplastic carcinoma of lung.

6. The changing histopathology of lung cancer: a review of 1682 cases.

7. Mitomycin-C alone and in combination with infused 5-fluorouracil to the treatment of disseminated gastrointestinal carcinomas.

8. 5-Fluorouracil, adriamycin, and mitomycin-C (FAM) chemotherapy for adenocarcinoma of the lung.

9. Clinical features of bronchogenic carcinoma in Hong Kong. Review of 480 patients.

10. Increasing incidence of adenocarcinoma of the lung.

Review 1. Combination chemotherapy for advanced adenocarcinoma of the lung. A review.