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Literature DB >> 392238

Three additional genes involved in pyrimidine dimer removal in Saccharomyces cerevisiae: RAD7, RAD14 and MMS19.

Abstract

The ability to remove ultraviolet (UV)-induced pyrimidine dimers from the nuclear DNA of yeast was examined in two radiation-sensitive (rad) mutants and one methyl methanesulfonate-sensitive (mms) mutant of the yeast Saccharomyces cerevisiae. The susceptibility of DNA from irradiated cells to nicking by an endonuclease activity prepared from crude extracts of Micrococcus luteus was used to measure the presence of dimers in DNA. The rad7, rad14 and mms19 mutants were found to be defective in their ability to remove UV-induced dimers from nuclear DNA. All three mutants belong to the same epistatic group as the other mutants involved in excision-repair. All three mutants show enhanced UV-induced mutations. The rad14 mutant also shows epistatic interactions with genes in the other two UV repair pathways.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1979 PMID： 392238 DOI： 10.1007/bf00333097

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

28 in total

1. Comparative analysis of deletion and base-change mutabilities of Escherichia coli B strains differing in DNA repair capacity (wild-type, uvrA-, polA-, recA-) by various mutagens.

Authors: Y Ishii; S Kondo
Journal: Mutat Res Date: 1975-01 Impact factor: 2.433

2. The disappearance of ultraviolet-induced pyrimidine dimers from the nuclear DNA of exponential and stationary phase cells of Saccharomyces cerevisiae following various post-irradiation treatments.

Authors: R Waters; E Moustacchi
Journal: Biochim Biophys Acta Date: 1974-07-24

3. Specificity and frequency of ultraviolet-induced reversion of an iso-1-cytochrome c ochre mutant in radiation-sensitive strains of yeast.

Authors: C W Lawrence; J W Stewart; F Sherman; R Christensen
Journal: J Mol Biol Date: 1974-05-05 Impact factor: 5.469

4. Base-change mutagenesis and prophage induction in strains of Escherichia coli with different DNA repair capacities.

Authors: S Kondo; H Ichikawa; K Iwo; T Kato
Journal: Genetics Date: 1970-10 Impact factor: 4.562

5. Genetic control of radiation sensitivity in Saccharomyces cerevisiae.

Authors: M A Resnick
Journal: Genetics Date: 1969-07 Impact factor: 4.562

6. The isolation, genetics and survival characteristics of ultraviolet light-sensitive mutants in yeast.

Authors: B S Cox; J M Parry
Journal: Mutat Res Date: 1968 Jul-Aug Impact factor: 2.433

7. UV mutagenesis in radiation-sensitive strains of yeast.

Authors: C W Lawrence; R Christensen
Journal: Genetics Date: 1976-02 Impact factor: 4.562

8. Defective thymine dimer excision in radiation-sensitive mutants rad10 and rad16 of Saccharomyces cerevisiae.

Authors: L Prakash
Journal: Mol Gen Genet Date: 1977-04-29

9. Repair of pyrimidine dimer damage induced in yeast by ultraviolet light.

Authors: M A Resnick; J K Setlow
Journal: J Bacteriol Date: 1972-03 Impact factor: 3.490

10. Induction of pure and sectored mutant clones in excision-proficient and deficient strains of yeast.

Authors: F Eckardt; R H Haynes
Journal: Mutat Res Date: 1977-06 Impact factor: 2.433

29 in total

1. Saccharomyces cerevisiae mms19 mutants are deficient in transcription-coupled and global nucleotide excision repair.

Authors: M Lombaerts; M Tijsterman; R A Verhage; J Brouwer
Journal: Nucleic Acids Res Date: 1997-10-15 Impact factor: 16.971

2. Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant.

Authors: L Queimado; M Rao; R A Schultz; E V Koonin; L Aravind; T Nardo; M Stefanini; E C Friedberg
Journal: Nucleic Acids Res Date: 2001-05-01 Impact factor: 16.971

3. The nucleotide sequence of the RAD3 gene of Saccharomyces cerevisiae: a potential adenine nucleotide binding amino acid sequence and a nonessential acidic carboxyl terminal region.

Authors: P Reynolds; D R Higgins; L Prakash; S Prakash
Journal: Nucleic Acids Res Date: 1985-04-11 Impact factor: 16.971

4. Repair of plasmid and genomic DNA in a rad7 delta mutant of yeast.

Authors: J P Mueller; M J Smerdon
Journal: Nucleic Acids Res Date: 1995-09-11 Impact factor: 16.971

5. Defective excision of pyrimidine dimers and interstrand DNA crosslinks in rad7 and rad23 mutants of Saccharomyces cerevisiae.

Authors: R D Miller; L Prakash; S Prakash
Journal: Mol Gen Genet Date: 1982

6. Genetic control of excision of Saccharomyces cerevisiae interstrand DNA cross-links induced by psoralen plus near-UV light.

Authors: R D Miller; L Prakash; S Prakash
Journal: Mol Cell Biol Date: 1982-08 Impact factor: 4.272

7. a/alpha-specific effect on the mms3 mutation on ultraviolet mutagenesis in Saccharomyces cerevisiae.

Authors: P Martin; L Prakash; S Prakash
Journal: J Bacteriol Date: 1981-05 Impact factor: 3.490

8. Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae: excision of dimers in cell extracts.

Authors: R J Reynolds; J D Love; E C Friedberg
Journal: J Bacteriol Date: 1981-08 Impact factor: 3.490

9. Incision and postincision steps of pyrimidine dimer removal in excision-defective mutants of Saccharomyces cerevisiae.

Authors: D R Wilcox; L Prakash
Journal: J Bacteriol Date: 1981-11 Impact factor: 3.490

10. The RAD24 (= Rs1) gene product of Saccharomyces cerevisiae participates in two different pathways of DNA repair.

Authors: F Eckardt-Schupp; W Siede; J C Game
Journal: Genetics Date: 1987-01 Impact factor: 4.562