| Literature DB >> 3921833 |
J P Kim, P D'Arpa, D Jacobson-Kram, J R Williams.
Abstract
The dose-response relationship for mitomycin-C (MMC)-induced sister-chromatid exchange (SCE) has been determined in the progeny of Chinese hamster lung fibroblasts (V79) exposed to 5.0 J/m2 ultraviolet light-C (UVC, 254 nm) and in the progeny of non-UVC-irradiated controls. Progeny of UVC-irradiated cultures exhibited sensitivity to MMC-induced SCE at doses of MMC that were not detectably lethal. This sensitivity was manifest as an increase in SCE per cell in a large proportion of the cells derived from UVC-exposed cultures and thus appears not to result from the expression of a rare event such as mutation.Entities:
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Year: 1985 PMID： 3921833 DOI： 10.1016/0027-5107(85)90161-7
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433