| Literature DB >> 3921437 |
Abstract
Eleven women with advanced ovarian cancer treated postoperatively with combination chemotherapy (cytoxan, hexamethylmelamine, Adriamycin, and cis-platinum) had disease-free intervals of 5 to 46 months (mean: 22 months) and subsequently developed recurrent carcinoma. Each patient was then retreated with combination chemotherapy which included cis-platinum. There was a 72% response rate to retreatment (36% complete, 36% partial). These overall and complete remission rates are comparable to those of platinum-based combination chemotherapy in patients without prior treatment. Those patients who responded to retreatment had a significantly longer mean survival rate than those who did not.Entities:
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Year: 1985 PMID: 3921437 DOI: 10.1016/0090-8258(85)90249-5
Source DB: PubMed Journal: Gynecol Oncol ISSN: 0090-8258 Impact factor: 5.482