A critical analysis of 75 therapeutic abortions.

An analysis is presented of the first 75 therapeutic abortions based on the results of laboratory investigations on midtrimester amniotic samples from 2816 pregnancies. The reasons for the abortions were: chromosome aberration (n = 36), male fetus at risk for X-linked disorder (n = 23), neural tube defect (n = 14), and metabolic disorders (n = 2). An estimation was made of the life expectancy of these 75 fetuses if no termination of pregnancy had taken place. We estimate that a maximum of about 40% of the aborted fetuses would have resulted in malformed children at the age of 1 year, or in boys developing serious disabilities during infancy. Financial (cost-benefit analysis) and psychologic aspects are discussed.