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Literature DB >> 3921306

The effect of piroxicam and auranofin on cell migration.

Abstract

Previous work at our laboratory has shown that Piroxicam is a potent inhibitor of neutrophil cell migration "in vitro". We have now extended these observations by comparing the effect of Piroxicam "in vivo" on neutrophil and monocyte chemotactic activity as well as comparing the findings with those obtained with Auranofin, a novel oral gold salt preparation. The data presented support the notion that Piroxicam appears to be an inhibitor of neutrophil cell function while Auranofin predominantly affects monocyte cell migration.

Entities: Chemical

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Year: 1985 PMID： 3921306 DOI： 10.1007/bf02032320

Source DB: PubMed Journal: Clin Rheumatol ISSN： 0770-3198 Impact factor: 2.980

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References

10 in total

1. Dissociation by piroxicam of degranulation and superoxide anion generation from decrements in chlortetracycline fluorescence of activated human neutrophils.

Authors: H S Edelson; H B Kaplan; H M Korchak; J E Smolen; G Weissmann
Journal: Biochem Biophys Res Commun Date: 1982-01-15 Impact factor: 3.575

7. Decreased lymphocyte response to PHA, Con-A, and calcium ionophore (A23187) in patients with RA and SLE, and reversal with levamisole in rheumatoid arthritis.

Authors: M A Scheinberg; L Santos; N F Mendes; C Musatti
Journal: Arthritis Rheum Date: 1978-04

The effect of piroxicam and auranofin on cell migration.

1. Dissociation by piroxicam of degranulation and superoxide anion generation from decrements in chlortetracycline fluorescence of activated human neutrophils.

2. Piroxicam enhances phagocytosis of Escherichia coli by human polymorphonuclear neutrophils.

3. Monocyte function in patients with solid neoplasms during immunotherapy with Corynebacterium parvum.

Review 4. Oxicams--a novel family of non-steroidal anti-inflammatory drugs.

5. Auranofin. New oral gold compound for treatment of rheumatoid arthritis.

6. Peripheral blood monocyte function in leprosy patients.

7. Decreased lymphocyte response to PHA, Con-A, and calcium ionophore (A23187) in patients with RA and SLE, and reversal with levamisole in rheumatoid arthritis.

8. The pathogenesis of rheumatoid arthritis and the immune response.

9. The effect of auranofin and sodium aurothiomalate on peripheral blood monocytes.

10. The effect of piroxicam on neutrophil and monocyte-macrophage function.