Apolipoprotein and lipid abnormalities in uremic children on hemodialysis.

Plasma lipids and six plasma apolipoproteins were studied in uremic children on hemodialysis. Significant increases in plasma triglyceride, apolipoproteins (Apo) C-II and C-III and decreases in total cholesterol, HDL-cholesterol, Apo A-I, Apo A-II and Apo B were found in uremic children. The levels of Apo C-I did not differ between uremic children and normal controls. The ratio of (Apo A-I + Apo A-II)/HDL-cholesterol was significantly increased. These results indicate that uremic children on hemodialysis have similar lipid and apolipoprotein abnormalities to those found in adults who may have a risk of cardiovascular disease.