Literature DB >> 392079

A randomized controlled trial of aspirin in the prevention of early mortality in myocardial infarction.

P C Elwood, W O Williams.   

Abstract

A randomized controlled trial is reported in which a single dose of aspirin (300 mg) was given to patients with myocardial infarction on first contact with a general practitioner. A total of 1,705 patients with confirmed infarction were studied, and survival ascertained. There was no evidence of benefit from the aspirin.

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Year:  1979        PMID： 392079      PMCID： PMC2159226     

Source DB:  PubMed          Journal:  J R Coll Gen Pract        ISSN： 0035-8797


  8 in total

1.  Inhibition of platelet release reaction by acetylsalicylic acid.

Authors:  R M Rowan; G A McDonald; R L Renton; S J Corne; D F Brown
Journal:  Postgrad Med J       Date:  1976-02       Impact factor: 2.401

Review 2.  Unstable metabolites of arachidonic acid and their role in haemostasis and thrombosis.

Authors:  S Moncada; J R Vane
Journal:  Br Med Bull       Date:  1978-05       Impact factor: 4.291

3.  Editorial: A revolution in coronary artery disease.

Authors:  J V Warren
Journal:  J Chronic Dis       Date:  1973-09

4.  Platelet aggregates and mural microthrombi in the early stages of acute, fatal coronary disease.

Authors:  J W Haerem
Journal:  Thromb Res       Date:  1974-08       Impact factor: 3.944

5.  Lung and heart lesions from intravascular platelet clumping and its sequelae.

Authors:  A Hughes; R S Tonks
Journal:  J Pathol Bacteriol       Date:  1968-04

6.  Platelet function studies in human beings receiving 300 mg. of aspirin per day.

Authors:  R K Stuart
Journal:  J Lab Clin Med       Date:  1970-03

Review 7.  Are agents affecting platelet functions clinically useful?

Authors:  M Verstraete
Journal:  Am J Med       Date:  1976-12       Impact factor: 4.965

8.  A randomized controlled trial of acetyl salicylic acid in the secondary prevention of mortality from myocardial infarction.

Authors:  P C Elwood; A L Cochrane; M L Burr; P M Sweetnam; G Williams; E Welsby; S J Hughes; R Renton
Journal:  Br Med J       Date:  1974-03-09
  8 in total
  7 in total

1.  Aspirin and acute myocardial infarction: clarifying the message.

Authors:  J Deeks; I Watt; N Freemantle
Journal:  Br J Gen Pract       Date:  1995-08       Impact factor: 5.386

Review 2.  Review of 39 years of randomized controlled trials in the British Journal of General Practice.

Authors:  C A Silagy; D Jewell
Journal:  Br J Gen Pract       Date:  1994-08       Impact factor: 5.386

3.  Aspirin in the prevention of myocardial infarction. Current status.

Authors:  P C Elwood
Journal:  Drugs       Date:  1984-07       Impact factor: 9.546

4.  High incarceration rates among black men enrolled in clinical studies may compromise ability to identify disparities.

Authors:  Emily A Wang; Jenerius A Aminawung; Christopher Wildeman; Joseph S Ross; Harlan M Krumholz
Journal:  Health Aff (Millwood)       Date:  2014-05       Impact factor: 6.301

5.  Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration.

Authors: 
Journal:  BMJ       Date:  1994-01-08

6.  Administration of zinc complex of acetylsalicylic acid after the onset of myocardial injury protects the heart by upregulation of antioxidant enzymes.

Authors:  Sevil Korkmaz-Icöz; Ayhan Atmanli; Tamás Radovits; Shiliang Li; Peter Hegedüs; Mihály Ruppert; Paige Brlecic; Yutaka Yoshikawa; Hiroyuki Yasui; Matthias Karck; Gábor Szabó
Journal:  J Physiol Sci       Date:  2015-10-23       Impact factor: 2.781

Review 7.  Aspirin in cardiovascular disease.

Authors:  I A Reilly; G A FitzGerald
Journal:  Drugs       Date:  1988-02       Impact factor: 9.546
  7 in total

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