Literature DB >> 3920312

Induction of interleukin 2 responsiveness in thymocytes by synergistic action of interleukin 1 and interleukin 2.

D N Männel, S B Mizel, T Diamantstein, W Falk.   

Abstract

Thymocyte cultures from C3H/HeJ mice were stimulated for proliferative responses with purified preparations of interleukin 1 (IL 1) and interleukin 2 (IL 2). Synergistic responses were obtained in the absence of mitogen. In the presence of excess IL 2, the thymocyte proliferation response was strictly dependent on the amount of IL 1 in the cultures. Antibodies to IL 1 inhibited the response in a dose-dependent manner. The combination of IL 1 plus IL 2 induced the appearance of IL 2 receptors on murine thymocytes as detected with a monoclonal antibody directed against the IL 2 receptor. Neither IL 1 nor IL 2 alone had this effect. The thymic subpopulation found to become IL 2 responsive upon IL 1 stimulus was the peanut agglutinin-negative (PNA-) medullary fraction.

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Year:  1985        PMID： 3920312

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  10 in total

1.  Comparison of lymphokine-activated killer activities between thymocytes and splenocytes in rats with brain tumors.

Authors:  H Matsuura; H Imaya
Journal:  Cancer Immunol Immunother       Date:  1991       Impact factor: 6.968

2.  Staphylococcus-mediated T-cell activation and spontaneous natural killer cell activity in the absence of major histocompatibility complex class II molecules.

Authors:  S K Chapes; S M Hoynowski; K M Woods; J W Armstrong; A A Beharka; J J Iandolo
Journal:  Infect Immun       Date:  1993-09       Impact factor: 3.441

3.  In vitro effects of gold sodium thiomalate on IL-1, IL-2 production, IL-2 receptor expression and IL-2 responsiveness in thymocytes and peripheral blood mononuclear cells.

Authors:  E Blitstein-Willinger; A Streller
Journal:  Clin Exp Immunol       Date:  1987-05       Impact factor: 4.330

4.  A monoclonal antibody inhibiting leucocyte adhesion blocks induction of IL-2 production but not IL-2 receptor expression.

Authors:  C Lindqvist; M Patarroyo; P G Beatty; H Wigzell
Journal:  Immunology       Date:  1987-04       Impact factor: 7.397

5.  Antigen-specific T-cell responses to a recombinant fowlpox virus are dependent on MyD88 and interleukin-18 and independent of Toll-like receptor 7 (TLR7)- and TLR9-mediated innate immune recognition.

Authors:  Erin L Lousberg; Kerrilyn R Diener; Cara K Fraser; Simon Phipps; Paul S Foster; Weisan Chen; Satoshi Uematsu; Shizuo Akira; Sarah A Robertson; Michael P Brown; John D Hayball
Journal:  J Virol       Date:  2011-01-19       Impact factor: 5.103

6.  Proliferation in vitro of Lyt2-,L3T4- thymocytes shows responsiveness to interleukin 1.

Authors:  G Chaudhri; I A Clark; R Ceredig
Journal:  Clin Exp Immunol       Date:  1988-07       Impact factor: 4.330

7.  Induction of lymphokine-activated killer cells from rat thymocytes using recombinant human interleukin-2.

Authors:  H Imaya; H Matsuura; M Kudo; S Nakazawa
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

8.  Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1.

Authors:  D Y Mochizuki; J R Eisenman; P J Conlon; A D Larsen; R J Tushinski
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

9.  T cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor.

Authors:  C Uyttenhove; P G Coulie; J Van Snick
Journal:  J Exp Med       Date:  1988-04-01       Impact factor: 14.307

10.  Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells.

Authors:  S L Koide; K Inaba; R M Steinman
Journal:  J Exp Med       Date:  1987-02-01       Impact factor: 14.307
  10 in total

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