Literature DB >> 3920311

Induction of IgG secretion in a human B cell clone with recombinant IL 2.

H Kishi, S Inui, A Muraguchi, T Hirano, Y Yamamura, T Kishimoto.   

Abstract

A human B cell clone (SGB3) responsive to IL 2 was established. Both recombinant IL 2 and B cell differentiation factor (BCDF) induced IgG secretion in SGB3 cells in a dose-dependent manner, but IL 2 did not affect the proliferation of SGB3 cells. FACS analysis showed that SGB3 cells expressed Tac antigen and anti-Tac antibody inhibited IL 2-induced IgG secretion without any inhibitory effect on BCDF-induced IgG secretion. These results showed that IL 2 could directly act on B cells and provide a differentiation signal through IL 2 receptors distinct from BCDF receptors. Physiologic relevance of IL 2 in the antibody response was discussed.

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Year:  1985        PMID： 3920311

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  9 in total

1.  CD25(+) Bcl6(low) T follicular helper cells provide help to maturing B cells in germinal centers of human tonsil.

Authors:  Haishan Li; C David Pauza
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2.  Cells and mediators which participate in immunoglobulin synthesis by human mononuclear cells. III. Null cells secrete a factor(s) (human immunoglobulin synthesis/secretion-facilitating factor) that can replace the null cells in the synthesis of immunoglobulin by cultured B cells.

Authors:  S Taylor; C A Jodouin; M Richter
Journal:  Clin Exp Immunol       Date:  1990-04       Impact factor: 4.330

Review 3.  Protein kinase C in IL-2 signal transduction.

Authors:  Y Lu; J P Durkin
Journal:  Immunol Res       Date:  1997       Impact factor: 2.829

4.  Distribution of lymphocytes with interleukin-2 receptors (TAC antigens) in reactive lymphoproliferative processes, Hodgkin's disease, and non-Hodgkin's lymphomas. An immunohistologic study of 300 cases.

Authors:  K Sheibani; C D Winberg; S van de Velde; D W Blayney; H Rappaport
Journal:  Am J Pathol       Date:  1987-04       Impact factor: 4.307

5.  Direct induction of human B-cell differentiation by recombinant interleukin-2.

Authors:  S Romagnani; G Del Prete; M G Giudizi; R Biagiotti; F Almerigogna; A Tiri; A Alessi; M Mazzetti; M Ricci
Journal:  Immunology       Date:  1986-05       Impact factor: 7.397

6.  Lysozyme as a regulator of interleukin-2-activated lymphocyte proliferation.

Authors:  N Yabe; K Komiya; T Takezono; H Matsui
Journal:  In Vitro Cell Dev Biol Anim       Date:  1993-10       Impact factor: 2.416

7.  Influence of IL-2 and IL-4 on the IgE synthesis and the IgE-binding factor (sCD23) production by human lymphocytes in vitro.

Authors:  I Knöller; J Bujanowski-Weber; B Brings; W König
Journal:  Immunology       Date:  1989-03       Impact factor: 7.397

8.  Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma.

Authors:  G Buchan; K Barrett; T Fujita; T Taniguchi; R Maini; M Feldmann
Journal:  Clin Exp Immunol       Date:  1988-02       Impact factor: 4.330

9.  Immunoglobulin production of human lymphocytes stimulated by Staphylococcus aureus Cowan I and pokeweed mitogen: differential effects of recombinant interleukin-2.

Authors:  J Pryjma; H D Flad; M Ernst; E Brandt; A J Ulmer
Journal:  Immunology       Date:  1986-12       Impact factor: 7.397
  9 in total

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