Literature DB >> 3920059

The benzodiazepine antagonist, Ro 15-1788 does not decrease ethanol withdrawal convulsions in rats.

H J Little, S C Taylor, D J Nutt, P J Cowen.   

Abstract

The effects of the benzodiazepine antagonist, Ro 15-1788 on ethanol withdrawal convulsions were investigated in rats. The study originated from recent reports of benzodiazepine binding activity in urine of alcoholics during withdrawal. No alleviation of convulsions was found with Ro 15-1788. This suggested that this component of the withdrawal syndrome is not due to endogenous production of a benzodiazepine inverse agonist (contragonist), as Ro 15-1788 prevents the action of this type of compound.

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Year:  1985        PMID： 3920059     DOI： 10.1016/0014-2999(85)90265-1

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  3 in total

1.  Flumazenil but not nitrendipine reverses the increased anxiety during ethanol withdrawal in the rat.

Authors:  S E File; H A Baldwin; P K Hitchcott
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

2.  The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress.

Authors:  Darin J Knapp; David H Overstreet; Robert A Angel; Montserrat Navarro; George R Breese
Journal:  Alcohol Clin Exp Res       Date:  2007-09-26       Impact factor: 3.455

3.  Similar effects of ethanol and flumazenil on acquisition of a shuttle-box avoidance response during withdrawal from chronic ethanol treatment.

Authors:  H E Criswell; G R Breese
Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739
  3 in total

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