Literature DB >> 3919734

gamma-Interferon stimulates production of 1,25-dihydroxyvitamin D3 by normal human macrophages.

H P Koeffler, H Reichel, J E Bishop, A W Norman.   

Abstract

We show for the first time that normal human pulmonary alveolar macrophages (PAM) markedly enhance their basal rate of the production of [3H]-1,25(OH)2D3 when cultured in the presence of recombinant gamma-interferon (gamma-IFN). The rate of conversion of [3H]-25(OH)D3 to [3H]-1,25(OH)2D3 was dose-dependent in a linear fashion. A maximal production of 1,25(OH)2D3 by PAM occurred after exposure of PAM to gamma-IFN for one day. This maximum plateau-level was sustained for at least five days. The authenticity of the putative 1,25(OH)2D3 obtained from PAM was tested by demonstrating the exact comigration of [3H]-1,25(OH)2D3 with chemically synthesized 1,25(OH)2D3 in four different HPLC-systems.

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Year:  1985        PMID： 3919734     DOI： 10.1016/s0006-291x(85)80202-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  58 in total

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Authors:  Rene F Chun; John S Adams; Martin Hewison
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Review 3.  Hormones and the immune response.

Authors:  A K Bhalla
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4.  1,25-Dihydroxycholecalciferol inhibits the cochemotactic activity of Gc (vitamin D binding protein).

Authors:  M Petrini; A Azzarà; G Carulli; B Grassi; F Ambrogi; R M Galbraith
Journal:  J Endocrinol Invest       Date:  1991-05       Impact factor: 4.256

5.  Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription.

Authors:  Marcos Vidal; Chilakamarti V Ramana; Adriana S Dusso
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

6.  Phagocytic cells synthesize 19-nor-10-keto-25-hydroxyvitamin D3, a metabolite that may induce differentiation of the human monoblastic cell line U937.

Authors:  T K Gray; D S Millington; D A Maltby; M E Williams; M S Cohen; R C Dodd
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

7.  The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury.

Authors:  Lige Song; Garyfallia Papaioannou; Hengguang Zhao; Hilary F Luderer; Christine Miller; Claudia Dall'Osso; Rosalynn M Nazarian; Amy J Wagers; Marie B Demay
Journal:  Endocrinology       Date:  2016-08-15       Impact factor: 4.736

8.  Vitamin D differentially regulates B7.1 and B7.2 expression on human peripheral blood monocytes.

Authors:  A Clavreul; C L D'hellencourt; C Montero-Menei; G Potron; D Couez
Journal:  Immunology       Date:  1998-10       Impact factor: 7.397

9.  Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA.

Authors:  W F Rigby; S Denome; M W Fanger
Journal:  J Clin Invest       Date:  1987-06       Impact factor: 14.808

10.  Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.

Authors:  Adrian F Gombart; Tsuyako Saito; H Phillip Koeffler
Journal:  BMC Genomics       Date:  2009-07-16       Impact factor: 3.969
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